01. Which one of the following drugs is an HMG COA REDUCTASE INHIBITORS (STATINS)?
A. Gemfibrizol
B. Atorvastatin
C. Niacin
D. Ezetimibe
E. Colesevelam
Answer: B. Atorvastatin
02. A drug that belongs to FIBRATES is one of the following?
A. Gemfibrizol
B. Atorvastatin
C. Niacin
D. Ezetimibe
E. Colesevelam
Answer: A. Gemfibrizol
A. Gemfibrizol
B. Atorvastatin
C. Niacin
D. Ezetimibe
E. Colesevelam
Answer: B. Atorvastatin
02. A drug that belongs to FIBRATES is one of the following?
A. Gemfibrizol
B. Atorvastatin
C. Niacin
D. Ezetimibe
E. Colesevelam
Answer: A. Gemfibrizol
03. A drug that belongs to nucleoside reverse transcriptase inhibitor?
A. AbacavirB. Delavirdine
C. Atazanavir
D. Maraviroc
E. Indanyl carbenicillin
Answer: A. Abacavir
04. A drug that belongs to the ACE inhibitors Class is the following?
A. Captopril
B. Bumetanide
C. Furosemide
D. Acebutolol
Answer: A. Captopril
05. Pralidoxime chloride is a drug that:
a) Blocks the active transport of choline into cholinergic neurons
b) Inhibits the reuptake of biogenic amines into nerve terminals
c) Reactivation of cholinesterases inhibited by organophosphate cholinesterase inhibitors
d) Reduces the vesicular stores of catecholamines in adrenergic and dopaminergic neurons
e) Stimulates the activity of phospholipase C with increased formation of inositol triphosphate
Answer: c) Reactivation of cholinesterases inhibited by organophosphate cholinesterase inhibitors
06. An antibacterial class of drugs that inhibit protein synthesis?
A. Clindamycin
B. Macrolide
C. Amphotericin B
D. Fluoroquinolone
E. A & B
Answer: E. A & B
13. What type of drug is Methacholine?
A. Cholinergic Agonist
B. Adrenergic Agonist
C. Cholinergic Antagonist
D. Cholinergic Antagonist
A. Clindamycin
B. Macrolide
C. Amphotericin B
D. Fluoroquinolone
E. A & B
Answer: E. A & B
07. A drug that is used to treat Helminthic infections for Cestodes is one of the following?
A. Cladribine
B. Praziquantel
C. Flucytosine
D. Etidronate
E. Niclosamide
Answer: E. Niclosamide
A. Cladribine
B. Praziquantel
C. Flucytosine
D. Etidronate
E. Niclosamide
Answer: E. Niclosamide
08. Which one of the following drugs is a second-line drug for tuberculosis?
A. Capreomycin
B. Rifamycin
C. Pyrazinamide
D. Isoniazid
Answer: A. Capreomycin
B. Glyburide
C. Pioglitazone
D. Sitagliptin
Answer: C. Pioglitazone
Because TZDs have the ability to Increase subcutaneous fat fluid retention leading to heart failure.
A. Capreomycin
B. Rifamycin
C. Pyrazinamide
D. Isoniazid
Answer: A. Capreomycin
09. Which one of the following is an antimuscarinic agent?
A. Neostigmine
B. Echothiophate
C. Cyclopentolate
D. Tacrine
E. Pralidoxime
Answer: C. Cyclopentolate
A. Neostigmine
B. Echothiophate
C. Cyclopentolate
D. Tacrine
E. Pralidoxime
Answer: C. Cyclopentolate
11. Which one of the following drugs has an adverse effect on Edema?
A. GlipizideB. Glyburide
C. Pioglitazone
D. Sitagliptin
Answer: C. Pioglitazone
Because TZDs have the ability to Increase subcutaneous fat fluid retention leading to heart failure.
12. What receptors does Bethanechol act on?
A. Muscarinic and Nicotinic
B. Muscarinic preferred
C. Nicotinic
D.None of the above is correct
Answer: B. Muscarinic preferred
A. Muscarinic and Nicotinic
B. Muscarinic preferred
C. Nicotinic
D.None of the above is correct
Answer: B. Muscarinic preferred
Used in treatment of urinary retention.
13. What type of drug is Methacholine?
A. Cholinergic Agonist
B. Adrenergic Agonist
C. Cholinergic Antagonist
D. Cholinergic Antagonist
Answer: A. Cholinergic agonist
14. What is Carbachol used to treat?
A. Asthma
B. Glaucoma
C. Urinary retention
D. Tachycardia
Answer: B. Glaucoma
Use in those patients who become tolerant to pilocarpine.
Produce miosis during ocular surgery. Used topically to reduce intraocular pressure in open angle glaucoma or narrow angle glaucoma,
15. When one of the following catecholamines is used as a drug, it's sometimes called levarterenol?
A. Epinephrine
B. Norepinephrine
C. Dopamine
D. Acetylcholine
E. Isoproterenol
Answer: Norepinephrine
15. When one of the following catecholamines is used as a drug, it's sometimes called levarterenol?
A. Epinephrine
B. Norepinephrine
C. Dopamine
D. Acetylcholine
E. Isoproterenol
Answer: Norepinephrine
16. Estimated Duration of phase 2 clinical trials?
A. Several Months
B. Two to five months
C. Several months to 2 years
D. Several years
E. Ten years
Answer: C. Several Months to 2 years
17. A total number of patients in phase 3 clinical trials?
A. Several Months
B. Two to five months
C. Several months to 2 years
D. Several years
E. Ten years
Answer: C. Several Months to 2 years
17. A total number of patients in phase 3 clinical trials?
A. 20 to 100
B. 500 to 1000
C. Several hundred patients
D. Several hundred to several thousand patients
E. 5000 patients
Answer: D. Several hundred to several thousand patients
18. Absence of hydrochloric acid from maximally stimulated gastric secretion is called?
A. Brugada syndrome
B. Agyria
C. Achlorhydria
D. Anoxaaemia
E. Denudation
Answer: C. Achlorhydria
C. Several hundred patients
D. Several hundred to several thousand patients
E. 5000 patients
Answer: D. Several hundred to several thousand patients
18. Absence of hydrochloric acid from maximally stimulated gastric secretion is called?
A. Brugada syndrome
B. Agyria
C. Achlorhydria
D. Anoxaaemia
E. Denudation
Answer: C. Achlorhydria
Infants are in state of achlorhydria (gastric PH> 4 ) because of reductions in basal acid secretion.
19. Dipivefrin is used to treat open-angle glaucoma is the prodrug of the following drug?
A. Clonidine
B. Imidazoline
C. Epinephrine
D. Dobutamine
E. Hydralazine
Answer: C. Epinephrine
19. Dipivefrin is used to treat open-angle glaucoma is the prodrug of the following drug?
A. Clonidine
B. Imidazoline
C. Epinephrine
D. Dobutamine
E. Hydralazine
Answer: C. Epinephrine
20. Glutathione depletion in the liver is caused by the following drugs at high doses?
A. Diflunisal
B. Leflunomide
C. Aspirin
D. Methotrexate
E. Acetaminophen
Answer: E. Acetaminophen
A. Diflunisal
B. Leflunomide
C. Aspirin
D. Methotrexate
E. Acetaminophen
Answer: E. Acetaminophen
Dose of NAC:
21. Which one of the following statements about the synthesis and release of NE from the adrenergic neuron is wrong?
A. Tyrosine is required and transported for dopamine synthesis
B. Dopamine is converted directly to epinephrine
C. NE is oxidized by MOA
D. NE is methylated by COMT
E. Inactive product of NE excreted in Urine
Answer: B. Dopamine is converted directly to epinephrine
B. Dopamine is converted directly to epinephrine
C. NE is oxidized by MOA
D. NE is methylated by COMT
E. Inactive product of NE excreted in Urine
Answer: B. Dopamine is converted directly to epinephrine
22. which one of the following statements about Beta-1 adrenoceptor effects is wrong?
A. Tachycardia
B. Increase lipolysis
C. Increase myocardial contractility
D. Relaxed uterine smooth muscle
E. increase release of renin
Answer: D. Relaxed uterine smooth muscle
B. Increase lipolysis
C. Increase myocardial contractility
D. Relaxed uterine smooth muscle
E. increase release of renin
Answer: D. Relaxed uterine smooth muscle
A. Alpha-1
B. Alpha -2
C. Beta-1
D. Beta 2
Answer: C. Beta-1
24. Uterine smooth muscle relaxation is specifically linked with which adrenoceptor?
A. Alpha-1
B. Alpha -2
C. Beta-1
D. Beta 2
Answer: Beta-2
A. Alpha-1
B. Alpha -2
C. Beta-1
D. Beta 2
Answer: Beta-2
25. Which one of the following drugs interferes with viral messenger RNA?
A. Zanamivir
B. Gancyclovir
C. Amantadine
D. Ribavirin
E. Interferon
Answer: D. Ribavirin
26. Cilastatin is used to protect one of the following drugs from metabolism by renal dehydropeptidase?
A. Cefepime
B. Imipenem
C. Aztreonam
D. Tazobactam
Answer: B. Imipenem
A. Zanamivir
B. Gancyclovir
C. Amantadine
D. Ribavirin
E. Interferon
Answer: D. Ribavirin
26. Cilastatin is used to protect one of the following drugs from metabolism by renal dehydropeptidase?
A. Cefepime
B. Imipenem
C. Aztreonam
D. Tazobactam
Answer: B. Imipenem
(High dose of Beta lactams especially imipenem causes seizures)
27. Which of the following tuberculosis drug causes Visual disturbance?
A. Isoniazid
B. Ethambutol
C. Rifampicin
D. Pyrazinamide
E. Streptomycin
Answer: B. Ethambutol
28. Ergosterol is the part of the cell membrane of the following?
A. Bacterial cell membrane
B. Viral Cell membrane
C. Fungal cell membrane
D. Protozoa cell membrane
Answer: C. Fungal cell membrane
The fungal cell membrane contains ergosterol as compared to cholesterol found in mammalian membranes.
29. Phosphodiesterase-6 is abundantly present in the following?
A. Retina
B. Corpus cavernosum
C. Medulla oblongata
D. Seminiferous tubules
Answer: A. Retina
Disturbance in color is caused by Sildenafil because it also inhibits PDE-6 found in the retina.
30. A 36 years old lady is taking imipramine for phobic anxiety disorder and her 25 years old husband is being treated with chlorpromazine for a psychotic disorder. Which of the following adverse effects is likely to occur in both of these individuals?
A. Decreased seizure threshold
B. Excessive salivation
C. Orthostatic hypotension
D. Pupillary constriction
E. Weight loss
Answer: C. Orthostatic hypotension.
31. Which one of the following statements about the use of Diflunisal NSAID is wrong?
A. 3-4 fold more potent than aspirin
B. No antipyretic activity
C. Can cross the Blood-brain barrier
D. Anti-inflammatory activity
Answer: C. Can cross the Blood-brain barrier
Can't cross the blood-brain barrier.
A. Isoniazid
B. Ethambutol
C. Rifampicin
D. Pyrazinamide
E. Streptomycin
Answer: B. Ethambutol
28. Ergosterol is the part of the cell membrane of the following?
A. Bacterial cell membrane
B. Viral Cell membrane
C. Fungal cell membrane
D. Protozoa cell membrane
Answer: C. Fungal cell membrane
The fungal cell membrane contains ergosterol as compared to cholesterol found in mammalian membranes.
29. Phosphodiesterase-6 is abundantly present in the following?
A. Retina
B. Corpus cavernosum
C. Medulla oblongata
D. Seminiferous tubules
Answer: A. Retina
Disturbance in color is caused by Sildenafil because it also inhibits PDE-6 found in the retina.
30. A 36 years old lady is taking imipramine for phobic anxiety disorder and her 25 years old husband is being treated with chlorpromazine for a psychotic disorder. Which of the following adverse effects is likely to occur in both of these individuals?
A. Decreased seizure threshold
B. Excessive salivation
C. Orthostatic hypotension
D. Pupillary constriction
E. Weight loss
Answer: C. Orthostatic hypotension.
31. Which one of the following statements about the use of Diflunisal NSAID is wrong?
A. 3-4 fold more potent than aspirin
B. No antipyretic activity
C. Can cross the Blood-brain barrier
D. Anti-inflammatory activity
Answer: C. Can cross the Blood-brain barrier
Can't cross the blood-brain barrier.
10. Which one of the following drugs has an adverse effect of Gastrointestinal disturbance (diarrhea, flatulence, and abdominal cramping) with no risk of hypoglycemia?
A. Acarbose
B. Miglitol
C. Sitagliptin
D. A & B
E. All of the above
Answer: D. A & B
Because these drugs delay the digestion of carbohydrates. Exert their effect by inhibiting Alpha-glucosidase enzyme in the intestinal brush border which is responsible for the hydrolysis of oligosaccharides yo Glucose and other sugars.
A. Acarbose
B. Miglitol
C. Sitagliptin
D. A & B
E. All of the above
Answer: D. A & B
Because these drugs delay the digestion of carbohydrates. Exert their effect by inhibiting Alpha-glucosidase enzyme in the intestinal brush border which is responsible for the hydrolysis of oligosaccharides yo Glucose and other sugars.
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