PHARMACOLOGY QUIZZES 22 | Multiple Choice Questions| Medical Exam Preparations

01. Which of the following drug is an HMG COA REDUCTASE INHIBITORS (STATINS)?
A. Niacin
B. Pravastatin
C. Fenofibrate
D. Ezetimibe
E. Colestipol

Answer: B. Pravastatin

02. A drug that belongs to CHOLESTEROL ABSORPTION INHIBITOR is one of the following?
A. Niacin
B. Fluvastatin
C. Fenofibrate
D. Ezetimibe
E. Colestipol

Answer: D. Ezetimibe

03. A drug that belongs to CLASS III?
A. Propafenone (IC)
B. Metoprolol
C. Amiodarone
D. Verapamil
E. Sotalol

Answer: E. Sotalol

04. A drug that belongs to CLASS III?
A. Quinidine (IA)
B. Sotalol
C. Amiodarone
D. Verapamil

Answer: B. Sotalol

05. Metformin belongs to one of the following classes of Oral hypoglycemic agents?
A. Thiazolidinediones 
B. Biguanide
C. Alpha-Glucosidase inhibitor
D. DPP-IV 

Answer: B. Biguanide

06. Which one of the following drugs belongs to ANTIMETABOLITES drugs for Cancer?
A. Methotrexate 
B. Capreomycin
C. Lamivudine 
D. Ezetimibe
E. Indanyl carbenicillin 

Answer: A. Methotrexate 

07. Which of the following drug is a part of drugs for subcutaneous and systemic mycoses?
A. Ibandronate
B.  Posaconazole
C. Capecitabine
D. Miconazole
E. Naftifine

Answer: B. Posaconazole

08. A drug that is used to treat Helminthic infections for nematodes is one of the following?
A. Cladribine
B. Ivermectin 
C. Flucytosine
D. Etidronate
E. Itraconazole

Answer: B. Ivermectin 

09. Which one of the following drugs is H2 antihistamine?
A. Rabeprazole
B. Sucralfate
C. Nizatidine
D. Alprostadil

Answer: C. Nizatidine

10. Streptomycin belongs to one of the following antibacterial classes?
A. Macrolide
B. Tetracyclines
C. Aminoglycoside
D. Fluoroquinolone

Answer: C. Aminoglycoside

11. Which one of the following vitamins increases the peripheral breakdown of Levodopa and decreases its effect when used alone?
A. Vitamin B3
B. Vitamin C
C. Vitamin B6
D. Vitamin A
E. Vitamin D

Answer: C. Vitamin B6 (pyridoxine)

13. All of the following result in detoxification of drugs except:
a. NADPH cytochrome P450 reductase
b. Cytochrome P450
c. Cytochrome Oxidase
d. Monoxygenases


Answer: C. Cytochrome Oxidase

14. The only drug whose overdose is not characterized by both hypotension and bradycardia:
a. Clonidine
b. Verapamil
c. Theophylline
d. Propanolol

Answer: Theophylline


15. Which among the following EICOSANOIDS lead to Bronchodilation?
a. PGE2
B. PGI2
C. PGF2 ALPHA
D. TXA2
e. Both C and D
F. Both A and B


Answer: F. Both A & B

16. Prostacyclin synthesized by endothelial cells act as?
A. Release of platelet granules 
B. Thromboxane A2 activation 
C. Inhibit platelet aggregation 
D. GP IIb/IIIa receptor activation 
E. Increase Ca+2 levels 


Answer: C. Inhibit platelet aggregation 


17. Following  binds to GP IIb/IIIa receptors on two separate platelets results in platelet cross-linking and platelet aggregation?
A. Fibrinogen 
B. Thrombin 
C. Thromboxane 
D. Serotonin 
E. PAF

Answer: A. Fibrinogen 


18.  Chemical mediators released by platelets except?
A. Thromboxane A2
B. ADP
C. Serotonin 
D. PAF
E. Prostacyclin 


Answer: E. Prostacyclin 

19. Pyridoxine is an antidote to one of the following drugs?

A. Iron
B. Organophosphate
C. Digoxin
D. Isoniazid

Answer: D. Isoniazid

20. Glutathione depletion in the liver is caused by the following drugs at high doses?
A. Diflunisal 
B. Leflunomide
C. Aspirin 
D. Methotrexate 
E. Acetaminophen 

Answer: E. Acetaminophen

21. Which one of the following drugs is injected subcutaneously once weekly to treat Hepatitis B?
A. Interferon-alpha-2a
B. Interferon alpha-2b
C. Peginterferon-alpha-2a
D. A & B
E. All of these 

Answer: C. Peginterferon-alpha-2a

22. Which of the following is the nonessential amino acid?
A. Asparagine 
B. Histidine 
C. Leucine 
D. Lycine
E. Methionine 

Answer:  A. Asparagine 

23. Urate retention which may precipitate a gouty attack caused by?
A. Pyrazinamide
B. Ethambutol
C. Rifabutin
D. A & B
E. All of the above

Answer: D. A & B

24. One of the following given drugs shows high efficacy when combined with a corticosteroid and is not recommended as monotherapy?
A. Formoterol
B. Albuterol
C. Metaproterenol
D. Epinephrine
E. Terbutaline

Answer: Formoterol

25. Which one of the following drugs causes the induction of cellular enzymes that interfere with viral protein synthesis?
A. Ribavirin
B. Zanamivir
C. Interferon-Alpha
D. Acyclovir

Answer: C. Interferon-Alpha

24. From FDA teratogenic risk categories studies in animals have revealed adverse effects on fetuses & there are no controlled studies in women. drugs should be given only if the potential benefit justifies the potential risk to the fetus?
A. categories B
B. categories C
C. categories D
D. categories A 

Answer: B. Categories C

25. Red-orange secretions and urine is caused by using one of the following tuberculosis drugs?
A. Isoniazid
B. Streptomycin
C. Ethambutol
D. Rifampicin
E. Pyrazinamide

Answer: D. Rifampicin

26. A patient receives Bethanechol after abdominal surgery. Her heart rate falls slightly and she experiences some wheezing. These cardiac and pulmonary responses represent: 
a) Expected side effects
b) Idiosyncrasy
c) Parasympathetic ganglion activation
d) Reflex suppression of the cardiac rate
e) Undiagnosed asthma

Answer: a) Expected side effects

27. Which one of the following statements about dobutamine is incorrect?
A. Positive inotropic effect   
B. 𝛃1 receptor stimulator 
C. Treat acute heart failure 
D. Increase myocardial cAMP 
E. Decrease contractility 

Answer: E. Decrease contractility

28. A fungistatic drug that also decreases testosterone and cortisol production is the following drug?
A. Ketoconazole
B. Amphotericin B
C. Flucytosine
D. Griseofulvin


Answer: A. Ketoconazole

29. Hepatosteatosis ( fatty liver) is an adverse effect of one of the following antiviral classes of drugs?
A. NRTIs
B. NNRTIs
C. HIV Protease inhibitors
D. Integrase inhibitors


Answer: A. NRTIs ( Nucleoside and nucleotide reverse transcriptase inhibitors)

30. Which of the following drugs block the binding of ADP to its receptor on platelets thus inhibiting the activation of GP IIa/IIIA receptors?
A. Ticlopidine
B. Clopidogrel
C. Aspirin
D. Both A & B
E. All of the above


Answer: D. Both A & B

31. An example of mutational change in DNA that can lead to abnormal protein such as a single nucleotide polymorphism (SNP) in the sequence of the coding DNA lead to alternate amino acid sequence?

A. Sickle cell anemia 

B. Tuberculosis 

C. Immunodeficiency 

D. Autoimmune disease 

Answer: A. Sickle cell anemia 

Normal adults: hemoglobin has glutamic acid at the sixth position in the beta globin protein chain.

Because of a Single mutation A-T, sickle cell patient have a Valine at 6th position. This change in beta globin structure leads to change in overall hemoglobin structure. This leads to sickle shape in the red blood cells and causes blockage in vessels called sickle cell crisis.

Common post transpational modification of specific amino acids 

12. Which one of the following drugs binds to the 30S Ribosomal subunit and distorts its structure along with misreading of the mRNA?
A. Erythromycin
B. Azithromycin
C. Gentamicin
D. Telithromycin


Answer: C. Gentamicin