MEDICOLOGY: Anticancer Drugs MCQS. 71

Wednesday, April 27, 2022

Anticancer Drugs MCQS. 71

01. A drug that inhibit the topoisomerase enzyme I reducing the supercoiling of DNA?
A. Irinotecan
B. Oxaliplatin 
C. Flutamide 
D. Tamoxifen 
E. Leuprolide 

Answer: A. Irinotecan (S phase specific)
Along with Topotecan, Etoposide, these drugs inhibit the topoisomerase enzymes I that is essential for replication of DNA in human cells.

02. Which of the following drugs inhibit topoisomerase I essential for replication of DNA in human cells?
A. Camptothecin derivative 
B. Abiraterone
C. Proteasome inhibitors 
D. Micro tubules inhibitors 
E. Alkylating agent 

Answer: A. Camptothecin derivative (Irinotecan, Topotecan)
Topotecan  is used in metastatic ovarian cancer and in the treatment of small lung cancer. While Irinotecan is used with 5-FU and Leucovorin for the treatment of colorectal carcinoma.

03. Which of the following drugs inhibit topoisomerase I essential for replication of DNA in human cells?
A. Irinotecan  
B. Abiraterone
C. Proteasome inhibitors 
D. Vincristine  
E. Carboplatin  

Answer: A. Irinotecan, Topotecan
Topotecan  is used in metastatic ovarian cancer and in the treatment of small lung cancer. While Irinotecan is used with 5-FU and Leucovorin for the treatment of colorectal carcinoma.

04. SN-38 the active metabolite of following drug and is approximately 1000 times as potent as an inhibitor of topoisomerase I?
A. Irinotecan 
B. Thalidomide 
C. Etoposide 
D. Topotecan 
E. Vinorelbine 

Answer: A. Irinotecan 

05. Acute and delayed life threatening diarrhoea is the adverse effect of following drug?
A. Irinotecan 
B. Thalidomide 
C. Etoposide 
D. Topotecan 
E. Vinorelbine 

Answer: A. Irinotecan 
That's why Irinotecan requires treatment with atropine during the infusion or high doses of loperamide in the days following the infusion.

06. Irinotecan drug treatment requires atropine during the infusion because of following symptom?
A. Hypertension 
B. Diarrhoea 
C. Dry cough 
D. Myelosuppression 
E. Neutropenia 

Answer: B. Diarrhoea 

07. Irinotecan drug treatment requires Loperamide during the infusion because of following symptom?
A. Hypertension 
B. Diarrhoea 
C. Dry cough 
D. Myelosuppression 
E. Neutropenia 

Answer: B. Diarrhoea 

08. Etoposide is a semisynthetic derivative of the plant alkaloid, podophyllotoxin has major target on cell?
A. Topoisomerase I
B. Topoisomerase II
C. Micro tubules 
D. Estrogen receptor
E. Replication of DNA

Answer: B. Topoisomerase II

09. Which of the following drugs block topoisomerase II in the late S to G2 phase of the cell cycle?
A. Topotecan 
B. Irinotecan 
C. Etoposide 
D. Thalidomide 
E. Vinorelbine 

Answer: C. Etoposide 
Persistent of the transient, Cleaveable form of the complex thus renders it susceptible to irreversible double strand breaks.

10. A drug that block the check points molecules such as programmed death (PD-1) receptor to attack the tumor and causes destruction?
A. Abiraterone
B. Thalidomide 
C. Nivolumab
D. Topotecan 
E. Etoposide 

Answer: C. Nivolumab

11. A drug that block the check points molecules such as programmed death (PD-1) receptor to attack the tumor and causes destruction?
A. Abiraterone
B. Thalidomide 
C. Pembrolizumab
D. Topotecan 
E. Etoposide 

Answer: C. Pembrolizumab  
These drugs block the immune check point molecules such as Programmed death (PD-1) receptor to help the immune system in check. After blocking these checkpoints immune system is better able to attack the tumor and cause destruction.
This causes severe and fatal immune mediated adverse events due to turning off the immune checkpoints and also it allows attack of the tumor. 

12. Mechanism  of action of Abiraterone acetate used in treatment of metastatic castration resistance prostate cancer?
A. Inhibit CYP17 enzyme 
B. Immune checkpoint inhibitor
C. Topoisomerase II inhibitor
D. Inhibit release of FSH and LH
E. Aromatase Inhibitor

Answer: A. Inhibit CYP17 enzyme ( An enzyme required for androgen synthesis). This block results in reduced testosterone production. 

13. Mechanism  of action of Anastrozole and Letrozole?
A. Inhibit CYP17 enzyme 
B. Immune checkpoint inhibitor
C. Topoisomerase II inhibitor
D. Inhibit release of FSH and LH
E. Aromatase Inhibitor

Answer: E. Aromatase inhibitor (Aromatase inhibitor decrease the production of Estrogen. Aromatase reaction is responsible for synthesis of Estrogen from androstenedione.

14. Mechanism  of action of Pembrolizumab and Nivolumab?
A. Inhibit CYP17 enzyme 
B. Immune checkpoint inhibitor
C. Topoisomerase II inhibitor
D. Inhibit release of FSH and LH
E. Aromatase Inhibitor

Answer:  B. Immune checkpoint inhibitor 

15. Mechanism  of action of Etoposide?
A. Inhibit CYP17 enzyme 
B. Immune checkpoint inhibitor
C. Topoisomerase II inhibitor
D. Inhibit release of FSH and LH
E. Aromatase Inhibitor

Answer:  C. Topoisomerase II inhibitor 

16. Mechanism  of action of Leuprolide, Goserelin, and Triptorelin?
A. Inhibit CYP17 enzyme 
B. Immune checkpoint inhibitor
C. Topoisomerase II inhibitor
D. Inhibit release of FSH and LH
E. Aromatase Inhibitor

Answer:  D. Inhibit release of FSH and LH 

17. Coadministration of following drug with Abiraterone acetate need to help lessen the effect of mineralocorticoid excess results from CYP17 inhibition?
A. Thalidomide 
B. Prednisone 
C. Etoposide 
D. Irinotecan 
E. Vinorelbine 

Answer: Prednisone 

18. A drugs work by inhibiting proteasome preventing the degradation of proapoptotic factors leading to promotion in programmed cell death (apoptosis)?
A. Bortezomib
B. Ixazomib
C. Carfilzomib
D. A & B
E. All of the above 

Answer: E. All of the above 

19. A drugs work by inhibiting proteasome preventing the degradation of proapoptotic factors leading to promotion in programmed cell death (apoptosis)?
A. Tamoxifen 
B. Ixazomib
C. Etoposide
D. A & B
E. All of the above 

Answer: B. Ixazomib
Along with Bortezomib and Carfilzomib

20. Mechanism of action of  Bortezomib, Ixazomib and Carfilzomib?
A. Proteasome inhibitor 
B. Estrogen release inhibitor 
C. Inhibit EGFR tyrosine kinase 
D. Inhibit mutated BRAF kinase 
E. Inhibit bruton tyrosine kinase 

Answer: A. Proteasome inhibitor 




  

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