A. Irinotecan
B. Oxaliplatin
C. Flutamide
D. Tamoxifen
E. Leuprolide
Answer: A. Irinotecan (S phase specific)
Along with Topotecan, Etoposide, these drugs inhibit the topoisomerase enzymes I that is essential for replication of DNA in human cells.
02. Which of the following drugs inhibit topoisomerase I essential for replication of DNA in human cells?
A. Camptothecin derivative
B. Abiraterone
C. Proteasome inhibitors
D. Micro tubules inhibitors
E. Alkylating agent
Answer: A. Camptothecin derivative (Irinotecan, Topotecan)
Topotecan is used in metastatic ovarian cancer and in the treatment of small lung cancer. While Irinotecan is used with 5-FU and Leucovorin for the treatment of colorectal carcinoma.
03. Which of the following drugs inhibit topoisomerase I essential for replication of DNA in human cells?
A. Irinotecan
B. Abiraterone
C. Proteasome inhibitors
D. Vincristine
E. Carboplatin
Answer: A. Irinotecan, Topotecan
Topotecan is used in metastatic ovarian cancer and in the treatment of small lung cancer. While Irinotecan is used with 5-FU and Leucovorin for the treatment of colorectal carcinoma.
04. SN-38 the active metabolite of following drug and is approximately 1000 times as potent as an inhibitor of topoisomerase I?
A. Irinotecan
B. Thalidomide
C. Etoposide
D. Topotecan
E. Vinorelbine
Answer: A. Irinotecan
05. Acute and delayed life threatening diarrhoea is the adverse effect of following drug?
A. Irinotecan
B. Thalidomide
C. Etoposide
D. Topotecan
E. Vinorelbine
Answer: A. Irinotecan
That's why Irinotecan requires treatment with atropine during the infusion or high doses of loperamide in the days following the infusion.
06. Irinotecan drug treatment requires atropine during the infusion because of following symptom?
A. Hypertension
B. Diarrhoea
C. Dry cough
D. Myelosuppression
E. Neutropenia
Answer: B. Diarrhoea
07. Irinotecan drug treatment requires Loperamide during the infusion because of following symptom?
A. Hypertension
B. Diarrhoea
C. Dry cough
D. Myelosuppression
E. Neutropenia
Answer: B. Diarrhoea
08. Etoposide is a semisynthetic derivative of the plant alkaloid, podophyllotoxin has major target on cell?
A. Topoisomerase I
B. Topoisomerase II
C. Micro tubules
D. Estrogen receptor
E. Replication of DNA
Answer: B. Topoisomerase II
09. Which of the following drugs block topoisomerase II in the late S to G2 phase of the cell cycle?
A. Topotecan
B. Irinotecan
C. Etoposide
D. Thalidomide
E. Vinorelbine
Answer: C. Etoposide
Persistent of the transient, Cleaveable form of the complex thus renders it susceptible to irreversible double strand breaks.
10. A drug that block the check points molecules such as programmed death (PD-1) receptor to attack the tumor and causes destruction?
A. Abiraterone
B. Thalidomide
C. Nivolumab
D. Topotecan
E. Etoposide
Answer: C. Nivolumab
11. A drug that block the check points molecules such as programmed death (PD-1) receptor to attack the tumor and causes destruction?
A. Abiraterone
B. Thalidomide
C. Pembrolizumab
D. Topotecan
E. Etoposide
Answer: C. Pembrolizumab
These drugs block the immune check point molecules such as Programmed death (PD-1) receptor to help the immune system in check. After blocking these checkpoints immune system is better able to attack the tumor and cause destruction.
This causes severe and fatal immune mediated adverse events due to turning off the immune checkpoints and also it allows attack of the tumor.
12. Mechanism of action of Abiraterone acetate used in treatment of metastatic castration resistance prostate cancer?
A. Inhibit CYP17 enzyme
B. Immune checkpoint inhibitor
C. Topoisomerase II inhibitor
D. Inhibit release of FSH and LH
E. Aromatase Inhibitor
Answer: A. Inhibit CYP17 enzyme ( An enzyme required for androgen synthesis). This block results in reduced testosterone production.
13. Mechanism of action of Anastrozole and Letrozole?
A. Inhibit CYP17 enzyme
B. Immune checkpoint inhibitor
C. Topoisomerase II inhibitor
D. Inhibit release of FSH and LH
E. Aromatase Inhibitor
Answer: E. Aromatase inhibitor (Aromatase inhibitor decrease the production of Estrogen. Aromatase reaction is responsible for synthesis of Estrogen from androstenedione.
14. Mechanism of action of Pembrolizumab and Nivolumab?
A. Inhibit CYP17 enzyme
B. Immune checkpoint inhibitor
C. Topoisomerase II inhibitor
D. Inhibit release of FSH and LH
E. Aromatase Inhibitor
Answer: B. Immune checkpoint inhibitor
15. Mechanism of action of Etoposide?
A. Inhibit CYP17 enzyme
B. Immune checkpoint inhibitor
C. Topoisomerase II inhibitor
D. Inhibit release of FSH and LH
E. Aromatase Inhibitor
Answer: C. Topoisomerase II inhibitor
16. Mechanism of action of Leuprolide, Goserelin, and Triptorelin?
A. Inhibit CYP17 enzyme
B. Immune checkpoint inhibitor
C. Topoisomerase II inhibitor
D. Inhibit release of FSH and LH
E. Aromatase Inhibitor
Answer: D. Inhibit release of FSH and LH
17. Coadministration of following drug with Abiraterone acetate need to help lessen the effect of mineralocorticoid excess results from CYP17 inhibition?
A. Thalidomide
B. Prednisone
C. Etoposide
D. Irinotecan
E. Vinorelbine
Answer: Prednisone
18. A drugs work by inhibiting proteasome preventing the degradation of proapoptotic factors leading to promotion in programmed cell death (apoptosis)?
A. Bortezomib
B. Ixazomib
C. Carfilzomib
D. A & B
E. All of the above
Answer: E. All of the above
19. A drugs work by inhibiting proteasome preventing the degradation of proapoptotic factors leading to promotion in programmed cell death (apoptosis)?
A. Tamoxifen
B. Ixazomib
C. Etoposide
D. A & B
E. All of the above
Answer: B. Ixazomib
Along with Bortezomib and Carfilzomib
20. Mechanism of action of Bortezomib, Ixazomib and Carfilzomib?
A. Proteasome inhibitor
B. Estrogen release inhibitor
C. Inhibit EGFR tyrosine kinase
D. Inhibit mutated BRAF kinase
E. Inhibit bruton tyrosine kinase
Answer: A. Proteasome inhibitor
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