A. Cisplatin
B. Ifosfamide
C. Irinotecan
D. Oxaliplatin
E. Doxorubicin
Answer: A. Cisplatin
02. Which of the following anticancer drugs causes Chemical Conjunctivitis?
A. Cisplatin
B. Ifosfamide
C. Cytarabine
D. Oxaliplatin
E. Doxorubicin
Answer: C. Cytarabine
03. Which of the following anticancer drugs causes Cardiotoxicity mainly?
A. Cisplatin
B. Ifosfamide
C. Irinotecan
D. Oxaliplatin
E. Doxorubicin
Answer: E. Doxorubicin
04. Which of the following anticancer drugs causes Diarrhoea?
A. Cisplatin
B. Ifosfamide
C. Irinotecan
D. Oxaliplatin
E. Doxorubicin
Answer: C. Irinotecan
05. Which of the following anticancer drugs causes Peripheral neuropathy?
A. Oxaliplatin
B. Vincristine
C. Taxanes
D. A & B
E. All of the above
Answer: E. All of the above
06. Which of the following anticancer drugs causes Hemorrhagic cystitis?
A. Cisplatin
B. Ifosfamide
C. Irinotecan
D. Oxaliplatin
E. Doxorubicin
Answer: B. Ifosfamide
07. Which of the following anticancer drugs causes Hemorrhagic cystitis?
A. Cisplatin
B. Cyclophosphamide
C. Irinotecan
D. Oxaliplatin
E. Doxorubicin
Answer: B. Cyclophosphamide
08. Which of the following anticancer drugs causes Pulmonary toxicity?
A. Cisplatin
B. Bleomycin
C. Irinotecan
D. Oxaliplatin
E. Doxorubicin
Answer: B. Bleomycin and Busulfan
09. Patients should receive antiviral prophylaxis for herpes zoster while undergoing treatment with which agent for multiple myeloma?
A. Bortezomib
B. Cisplatin
C. Ipilimumab
D. Dabrafenib
Answer: A. Bortezomib
10. Which of the following drugs causes herpes zoster reactivation in patients receiving treatment for multiple myeloma?
A. Bortezomib
B. Cisplatin
C. Ipilimumab
D. Dabrafenib
Answer: A. Bortezomib
Patients should receive antiviral prophylaxis while on Bortezomib therapy. Also Ixazomib has similar case
11. A drug causes severe birth defects when used in morning sickness?
A. Thalidomide
B. Lenalidomide
C. Pomalidomide
D. A & B
E. All of the above
Answer: E. All of the above
12. Following should be administered prior to an infusion of the monoclonal antibody rituximab?
A. Allopurinol and acetaminophen
B. Folic acid and H2 receptor antagonist
C. Antihistamine and acetaminophen
D. Hepatitis B & Vitamin B12
Answer: C. Antihistamine and acetaminophen
13. On the first cycle, patient experience an infusion reaction (hypotension, bronchospasm, angioedema) after receiving following?
A. Cetuximab
B. Rituximab
C. Bortezomib
D. Iplimumab
Answer: B. Rituximab
That's why antihistamine and acetaminophen and corticosteroids pretreatment is required to reduce these effects.
Slower infusion rate also reduce infusion reaction.
Along with these symptoms fever and chills also occurs especially in patients with high circulating levels of neoplastic cells because of rapid activation of complement which results in release of tumor necrosis factor-alpha and interleukin.
14. Pretreatment with Antihistamine and acetaminophen reduce the infusion reaction prior to administration of following monoclonal antibody?
A. Rituximab
B. Bortezomib
C. Cetuximab
D. A & B
E. All of the above
Answer: A. Rituximab
15. Appearance of facial rash with Cetuximab is associated with a?
A. Negative response to therapy
B. Positive response to therapy
C. Drug allergy
D. Infusion reaction
Answer: B. Positive response to therapy
Cetuximab is a monoclonal antibody that inhibit epidermal growth factor receptor (EGFR). Patients receiving this therapy develop an acneiform like rash on the face, chest, upper back and arms. This rash appearance has correlated with an increased response of therapy.
16. Appearance of facial rash is correlated with increased and positive response to therapy of following drug?
A. Bortezomib
B. Cetuximab
C. Sunitinib
D. Thalidomide
E. Etoposide
Answer: B. Cetuximab (inhibit EGFR)
17. Infusion related reactions such as hypotension, bronchospasm, and angioedema are common with following anticancer therapy?
A. Tyrosine kinase inhibitors
B. Immunotherapy
C. Monoclonal antibody therapy
D. Steroids therapy
E. Antibiotics therapy
Answer: C. Monoclonal antibody therapy
18. A 64 year old man is scheduled to undergo chemotherapy for rhabdomyosarcoma, and the regimen includes ifosfamide. Which is most appropriate to include in chemotherapy orders for this patient?
A. IV hydration, mesna and frequent urinalysis
B. Leucovorin and frequent urinalysis
C. Allopurinol and frequent urinalysis
D. IV hydration, prophylactic antibiotics and frequent urinalysis
Answer: A. IV hydration, mesna and frequent urinalysis
19. A unique toxicity of ifosfamide is following?
A. Haemorrhagic cystitis
B. Diarrhoea
C. Cardio toxicity
D. Ototoxicity
Answer: A. Haemorrhagic cystitis
20. Bladder toxicity (Haemorrhagic cystitis) is caused by the toxic metabolites of following drug?
A. Cisplatin
B. Cytarabine
C. Ifosfamide
D. Bleomycin
E. Irinotecan
Answer: C. Ifosfamide
To neutralise these toxic metabolites, adequate hydration as well as IV injection of mesna (sodium 2-mercaptoethane sulfonate) can minimise Bladder toxicity. Also frequent urinalysis to monitor for red blood cells should be ordered.
21. IV adequate hydration, IV injection of mesna (sodium 2-mercaptoethane sulfonate) and frequent urinalysis can minimise Bladder toxicity in chemotherapy of following drug?
A. Methotrexate
B. 5-FU
C. Ifosfamide
D. Vincristine
E. Dacarbazine
Answer: C. Ifosfamide
Ifosfamide causes bladder toxicity (Haemorrhagic cystitis).
No comments:
Post a Comment