MEDICOLOGY: Anticancer Drugs MCQS. 72

Wednesday, April 27, 2022

Anticancer Drugs MCQS. 72

01. Which of the following anticancer drugs causes Ototoxicity?
A. Cisplatin
B. Ifosfamide
C. Irinotecan 
D. Oxaliplatin 
E. Doxorubicin 

Answer: A. Cisplatin

02. Which of the following anticancer drugs causes Chemical Conjunctivitis?
A. Cisplatin
B. Ifosfamide
C. Cytarabine  
D. Oxaliplatin 
E. Doxorubicin 

Answer: C. Cytarabine 

03. Which of the following anticancer drugs causes Cardiotoxicity mainly?
A. Cisplatin
B. Ifosfamide
C. Irinotecan 
D. Oxaliplatin 
E. Doxorubicin 

Answer: E. Doxorubicin 

04. Which of the following anticancer drugs causes Diarrhoea?
A. Cisplatin
B. Ifosfamide
C. Irinotecan 
D. Oxaliplatin 
E. Doxorubicin 

Answer: C. Irinotecan 

05. Which of the following anticancer drugs causes Peripheral neuropathy?
A. Oxaliplatin
B. Vincristine 
C. Taxanes 
D. A & B 
E. All of the above 

Answer: E. All of the above 

06. Which of the following anticancer drugs causes Hemorrhagic cystitis?
A. Cisplatin
B. Ifosfamide
C. Irinotecan 
D. Oxaliplatin 
E. Doxorubicin 

Answer: B. Ifosfamide

07. Which of the following anticancer drugs causes Hemorrhagic cystitis?
A. Cisplatin
B. Cyclophosphamide 
C. Irinotecan 
D. Oxaliplatin 
E. Doxorubicin 

Answer: B. Cyclophosphamide 

08. Which of the following anticancer drugs causes Pulmonary toxicity?
A. Cisplatin
B. Bleomycin
C. Irinotecan 
D. Oxaliplatin 
E. Doxorubicin 

Answer: B. Bleomycin and Busulfan

09. Patients should receive antiviral prophylaxis for herpes zoster while undergoing treatment with which agent for multiple myeloma?
A. Bortezomib 
B. Cisplatin
C. Ipilimumab
D. Dabrafenib

Answer: A. Bortezomib 

10. Which of the following drugs causes herpes zoster reactivation in patients receiving treatment for multiple myeloma?
A. Bortezomib 
B. Cisplatin
C. Ipilimumab
D. Dabrafenib

Answer: A. Bortezomib 
Patients should receive antiviral prophylaxis while on Bortezomib therapy. Also Ixazomib has similar case

11. A drug causes severe birth defects when used in morning sickness?
A. Thalidomide 
B. Lenalidomide
C. Pomalidomide
D. A & B
E. All of the above 

Answer: E. All of the above 

12. Following should be administered prior to an infusion of the monoclonal antibody rituximab?
A. Allopurinol and acetaminophen 
B. Folic acid and H2 receptor antagonist 
C. Antihistamine and acetaminophen 
D. Hepatitis B & Vitamin B12

Answer: C. Antihistamine and acetaminophen 

13. On the first cycle, patient experience an infusion reaction (hypotension, bronchospasm, angioedema) after receiving following?
A. Cetuximab
B. Rituximab
C. Bortezomib 
D. Iplimumab

Answer: B. Rituximab
That's why antihistamine and acetaminophen and corticosteroids pretreatment is required to reduce these effects.
Slower infusion rate also reduce infusion reaction. 
Along with these symptoms fever and chills also occurs especially in patients with high circulating levels of neoplastic cells because of rapid activation of complement which results in release of tumor necrosis factor-alpha and interleukin.

14. Pretreatment with Antihistamine and acetaminophen reduce the infusion reaction prior to administration of following monoclonal antibody?
A. Rituximab 
B. Bortezomib 
C. Cetuximab
D. A & B
E. All of the above 

Answer: A. Rituximab  

15. Appearance of facial rash with Cetuximab is associated with a?
A. Negative response to therapy 
B. Positive response to therapy 
C. Drug allergy 
D. Infusion reaction 

Answer: B. Positive response to therapy 
Cetuximab is a monoclonal antibody that inhibit epidermal growth factor receptor (EGFR). Patients receiving this therapy develop an acneiform like rash on the face, chest, upper back and arms. This rash appearance has correlated with an increased response of therapy.

16. Appearance of facial rash is correlated with increased and positive response to therapy of following drug?
A. Bortezomib 
B. Cetuximab 
C. Sunitinib
D. Thalidomide 
E. Etoposide 

Answer: B. Cetuximab (inhibit EGFR)

17. Infusion related reactions such as hypotension, bronchospasm, and angioedema are common with following anticancer therapy?
A. Tyrosine kinase inhibitors 
B. Immunotherapy 
C. Monoclonal antibody therapy 
D. Steroids therapy 
E. Antibiotics therapy 

Answer: C. Monoclonal antibody therapy 

18. A 64 year old man is scheduled to undergo chemotherapy for rhabdomyosarcoma, and the regimen includes ifosfamide. Which is most appropriate to include in chemotherapy orders for this patient?
A. IV hydration, mesna and frequent urinalysis 
B. Leucovorin and frequent urinalysis 
C. Allopurinol and frequent urinalysis 
D. IV hydration, prophylactic antibiotics and frequent urinalysis 

Answer: A. IV hydration, mesna and frequent urinalysis 

19. A unique toxicity of ifosfamide is following?
A. Haemorrhagic cystitis 
B. Diarrhoea 
C. Cardio toxicity 
D. Ototoxicity

Answer: A. Haemorrhagic cystitis 

20. Bladder toxicity (Haemorrhagic cystitis) is caused by the toxic metabolites of following drug?
A. Cisplatin
B. Cytarabine 
C. Ifosfamide 
D. Bleomycin 
E. Irinotecan 

Answer: C. Ifosfamide 
To neutralise these toxic metabolites, adequate hydration as well as IV injection of mesna (sodium 2-mercaptoethane sulfonate) can minimise Bladder toxicity. Also frequent urinalysis to monitor for red blood cells should be ordered. 

21. IV adequate hydration, IV injection of mesna (sodium 2-mercaptoethane sulfonate) and frequent urinalysis can minimise Bladder toxicity in chemotherapy of following drug?
A. Methotrexate 
B. 5-FU
C. Ifosfamide 
D. Vincristine 
E. Dacarbazine

Answer: C. Ifosfamide 
Ifosfamide causes bladder toxicity (Haemorrhagic cystitis).





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