A. Allopurinol
B. 5-fluorouracil
C. Ifosfamide
D. Mesna
E. Leucovorin
Answer: E. Leucovorin
Leucovorin is used to reverse the inhibition of dihydrofolate reductase enzyme that is needed to convert folic acid to its active tetrahydrofolic acid (FH4).
02. Which of the following drugs is antidote of Methotrexate?
A. Allopurinol
B. Vincomycin
C. Warfarin
D. Naloxone
E. Leucovorin
Answer: E. Leucovorin
Two more antidotes, thymidine and glucarpidase
03. Dihydrofolate reductase enzyme that convert folic acid to active tetrahydrofolic acid (FH4) in inhibited by?
A. Methotrexate
B. Etoposide
C. Cisplatin
D. Fludarabine
E. 6-mercapopurine
Answer: A. Methotrexate
Also Pemetrexed and Pralatrexate.
04. Dihydrofolate reductase enzyme that convert folic acid to active tetrahydrofolic acid (FH4) in inhibited by?
A. Pemetrexed
B. Etoposide
C. Cisplatin
D. Fludarabine
E. 6-mercapopurine
Answer: A. Methotrexate
Also methotrexate and Pralatrexate.
05. Chemotherapy given before the surgical procedure in an attempt to shrink the cancer is called?
A. Adjuvant
B. Neoadjuvant
C. Palliative
D. Maintenance
Answer: B. Neoadjuvant
06. A patient is about to undergo the three cycle of chemotherapy prior to surgery for bladder. Which best describes chemotherapy in this setting?
A. Adjuvant
B. Neoadjuvant
C. Palliative
D. Maintenance
Answer: B. Neoadjuvant
07. Chemotherapy given in lower doses to assist in prolonging a remission is known as?
A. Adjuvant
B. Neoadjuvant
C. Palliative
D. Maintenance
Answer: D. Maintenance
08. Chemotherapy is indicated when neoplasm are disseminated and are not able to surgery. This therapy is called?
A. Adjuvant
B. Neoadjuvant
C. Palliative
D. Maintenance
Answer: C. Palliative
In advance stages of cancer, controlling the cancer is low and the goal is palliative ( alleviation of symptoms and avoidance of life threatening toxiy. Survival is extended with this therapy but the patient eventually dies of the disease.
09. In advance stages of cancer, controlling the cancer is low and the goal is alleviation of symptoms and avoidance of life threatening toxicity?therapy called?
A. Adjuvant
B. Neoadjuvant
C. Palliative
D. Maintenance
Answer: C. Palliative therapy
10. Chemotherapy used as supplemental treatment to attack micrometastases following surgery and radiation treatment is called?
A. Adjuvant
B. Neoadjuvant
C. Palliative
D. Maintenance
Answer: A. Adjuvant
11. Which of the following cells are more sensitive to chemotherapy?
A. Rapidly dividing cells
B. Slowly proliferating cells
C. Nondividing Cells
D. Normal cells
Answer: Rapidly dividing cells
Less sensitive to slowly proliferating cells while non dividing cells (G0 phase) servive the toxic effects of many chemotherapy drugs.
12. Leukaemic or other tumor cells find sanctuary in tissue such as CNS where some chemotherapeutic drugs can't enter. Which of the following route is suitable to eliminate these cells?
A. Oral
B. Intrathecal
C. Sublingual
D. Intramuscular
Answer: B. Intrathecal
Some drugs are unable to penetrate certain areas of solid tumours.
13. Which of the following is the advantage of combination chemotherapy?
A. Max cell killing within tolerated toxicity
B. Delay the development of resistant cell lines
C. Prevent the development of resistant cell lines
D. Effective against broader range of cell lines
E. All of these
Answer: E. All of these
14. Inhibit the de novo synthesis of purine ring and inhibit nucleotide interconversions?
A. 6-Mercaptopurine
B. 6- Thioguanine
C. Methotrexate
D. A & B
E. All of the above
Answer: D. A & B
Both drugs are purine antimetabolites and 6MP is a thiol analog of hypoxanthine. First purine analog to treat neoplastic disease in acute lymphoblastic leukaemia also in Crohn's disease.
15. Azathioprine is an immunosuppressant exert its cytotoxic effects after conversion to following drug?
A. 6-Mercaptopurine
B. 5-Fluorouracil
C. Fludarabine
D. Capecitabine
E. Cytarabine
Answer: A. 6-Mercaptopurine
Because Azathioprine is an analog of 6-MP and is benificial in treating Crohn disease.
16. 6-Mercaptopurine along with its following analog is benificial in treating Crohn's disease?
A. Methotrexate
B. 6-Thioguanine
C. 5-Fuorouracil
D. Azathioprine
E. Capecitabine
Answer: D. Azathioprine
It's an immunosuppressant drug.
17. Dose of 6-Mercaptopurine is reduced by 50%_70% when used with following drug to prevent toxicity?
A. Methotrexate
B. 6-Thioguanine
C. 5-Fuorouracil
D. Azathioprine
E. Capecitabine
Answer: D. Azathioprine
It's an immunosuppressant drug.
18. Inhibition of dihydrofolate reductase leads to an inhibition of purine ring and dTMP biosynthesis?
A. 6-Mercaptopurine
B. 6- Thioguanine
C. Methotrexate
D. A & B
E. All of the above
Answer: C. Methotrexate
dTMP( deoxythymidine monophosphate
19. Which of the following statements about Antimetabolites is wrong?
A. Structurally related to cell compounds
B. Interfare with purine & pyrimidine
C. Inhibit synthesis of Purine and pyrimidine
D. Max cytotoxic effect in S phase
E. Cell cycle nonspecific
Answer: E. Cell cycle nonspecific
20. Which of the following statements is incorrect about Folic Acid?
A. Obtained from dietary sources
B. Produced by intestinal flora
C. Transfer one carbon unit in metabolic reaction
D. Essential for cell replication
E. Methotrexate is an agonist of Folic acid
Answer: E. Methotrexate is an agonist to folic acid
Methotrexate (MTX) is an antagonist to folic acid and is structurally related to folic acid
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