PHARMACOLOGY QUIZZES 01 | Multiple Choice Questions| Medical Exam Preparations

01. Which one of the following drugs is an integrase inhibitor?
A. Maraviroc
B. Ritonavir
C. Raltegravir
D. Delavirdine

Answer: C. Raltegravir

02. Zanamivir belongs to the class of the following drugs?
A. Antiviral 
B. Antipyretic 
C. Antiprotozoal
D. Antibiotics 
E. Anti-malaria 

Answer: A. Antiviral

03. Ciprofloxacin belongs to the class of the following drugs?
A. Antiviral 
B. Antipyretic 
C. Antiprotozoal
D. Antibiotics 
E. Anti-malaria 

Answer: D. Antibiotics 

04.  A drug that is used to treat Helminthic infections for nematodes is one of the following?
A. Cladribine
B. Pyrantel pamoate
C. Flucytosine
D. Etidronate
E. Itraconazole

Answer: B. Pyrantel pamoate 

05. A drug that is used to treat Helminthic infections for nematodes is one of the following?
A. Cladribine
B.  thiabendazole
C. Flucytosine
D. Etidronate
E. Itraconazole

Answer: B. Thiabendazole 

06. Which of the following drugs is used as a first-line drug to treat tuberculosis?
A. Ethambutol 
B. Isoniazid
C. Pyrazinamide
D. Rifamycin
E. All of the above

Answer: E. All of the above

07. A drug that is used to treat Helminthic infections for trematodes is one of the following?
A. Cladribine
B. Praziquantel 
C. Flucytosine
D. Etidronate
E. Itraconazole

Answer: B. Praziquantel 

08. Which of the following drug provides relief in benign hypertrophy of the prostate other than 5-Alpha reductase inhibitor?
A. Tamsulosin
B. Desmopressin
C. Finasteride
D. Sildenafil
E. Terbutaline

Answer
1. Tamsulosin and Alfuzosin are alpha¹ selective inhibitors and Adrenergic drugs used for Benign prostatic hyperplasia or BPH. Benign prostatic hyperplasia is a Prostate gland disease in which the Prostate (located beneath the bladder) size is increased or enlarged,  it started blocking urine flow out of the urethra. Because the tube that passes urine from the bladder to the urethra passes through the center of the prostate. Thus, when the size is enlarged then it blocks Urine.
MOA of TAMSULOSIN:
Tamsulosin started relaxing the muscle of the bladder neck and muscles in the prostate to unblock the passage of Urine.
While about other drugs that are not used for BPH:
Desmopressin is an antidiuretic Hormone along with Vasopressin activates V2 receptors in renal collecting tubules to reabsorb the water from collecting ducts.
Finasteride is a 5-alpha reductase inhibitor that is also used in BPH which stopped the conversion of testosterone to dihydrotestosterone. 
Sildenafil is a Selective inhibitor of phosphodiesterases. 
Terbutaline is a short-acting agonist of Beta-2 used as a bronchodilator.

09. Tamsulosin is selective for the following antagonist that is used to treat benign prostate hyperplasia?
A. α1A
B. α1B
C. α1C
D. α1D
E. α1E

Answer: A. α1A

10. Thyroid hormone secretion and transport are controlled by thyroid-stimulating hormone?
A. Calcitonin 
B. Thyrotropin
C. Thyroxine 
D. Triiodothyronine 
E. Thyronorm

Answer: thyrotropin

11. Thyroid gland secrets following hormone except?
A. Thyroxine 
B. Thyronorm
C. Triiodothyronine 
D. Calcitonin 
E. None 

Answer: B. Thyronorm 

12. Which one of the following statements about the use of Aspirin is wrong?
A. Strong organic acid 
B. Irreversibly acetylate COX
C. Block prostaglandin synthesis 
D. Depress pain stimuli
E. Causes Reye's syndrome 

Answer: A. Strong organic acid 
Aspirin is a weak organic acid.

13. A drug that causes inhibition of viral DNA polymerase and reverse transcriptase at the pyrophosphate binding site?
A. Zanamivir 
B. Foscarnet  
C. Amantadine
D. Ribavirin 
E. Interferon 

Answer: B. Foscarnet

An antiviral drug used to treat herpesvirus infection. 

Reversibly inhibit DNA & RNA synthesis, not a purine or pyrimidine analog. Causes chelation with divalent cations. Hypocalcemia and hypomagnesemia cause.

14. Absorption of the following drugs is increased when taken with a fatty meal?
A. Zanamivir 
B. Ribavirin 
C. Oseltamivir 
D. A & B 
E.  None of these 

Answer: B. Ribavirin

15. A drug that has high oral bioavailability than others is following?
A. Gancyclovir
B. Valganciclovir
C. Penciclovir
D. Fomivirsen 
E. Vidarabine

Answer: B. Valganciclovir

16. Which one of the following statements about the use of Alpha1-adrenoceptor-blocking drugs is wrong?
A. Decrease peripheral resistance
B. Causes postural hypotension
C. tamsulosin used for prostate hyperplasia
D. Clonidine causes Sedation

Answer: D. Clonidine causes Sedation
Clonidine is not an Alpha-adrenoceptor blocking drug. it's an Alpha-2 agonist.

17. Phenylephrine has a high affinity for following adrenoceptors type?
A. α1 Receptors
B. α2 Receptors
C. α1 & B1 Receptors
D. Both A & B
E. All of these 

Answer: A. α1  Receptors

18. 3-5 Hours is the effective duration of action of following insulin type?
A. Glulisine
B. Regular
C. NPH
D. Glargine

Answer: A. Glulisine

Note: Human insulin was the first therapeutic compound produced through biotechnology.

19. Alopecia is an adverse effect of one of the following drugs?
A. Allopurinol
B. Colchicine
C. Aspirin 
D. Abatacept

Answer: B. Colchicine

20. Agranulocytosis aplastic anemia is an adverse effect of one of the following drugs?
A. Colchicine
B. Allopurinol
C. Cetirizine
D. Abacavir

Answer: A. Colchicine

21. Which drug is relatively free of drug-drug interaction?

A. Voriconazole 

B. Itraconazole 

C. Caspofungin  

D. Terbinafine 

Answer: C. Caspofungin  

All three Echinocandins are not metabolized by the CYP enzyme system so they have very few drug interactions. All other drugs are metabolized by the CYP450 enzyme system.

22. If iron or lithium was ingested and charcoal may be inappropriate to wash out the GI tract, what Amount of PEG electrolyte is used in adults?

A. 25mL/kg per hour (approx. 500mL/h)

B. 50mL/h up to 3 L

C. 2L/h up to 5-10 L

D. None of these 

Answer: C. 2L/h upto 5-10 L in adults 

In children 25mL/kg per hour (approx. 500mL/h 2-5L)

PEG is used to wash the GI tract when the toxin is suspected to be present in the GI tract e.g drugs are sustained release.

Amount of Activated Charcoal: Adults: 25-100g

Children: 25-50g

23. A drug is used to treat adverse reactions to drugs that produce free radicals?

A. Fomepizole 

B. Acetylcysteine

C. Flumazenil 

D. Sodium chloride 

Answer: B. Acetylcysteine is used to treat acute acetaminophen overdose by supplying glutathione to help in the metabolism of the reactive metabolites.

24. A drug promotes the redistribution of digoxin in plasma from tissues and enhances elimination in the urine is following?

A. Flumazenil 

B. Atropine 

C. Fomepizole 

D. Digoxin immune Fab

E. Ethanol 

Answer: D. Digoxin immune Fab produced in sheep to treat digoxin toxicity 

Digoxin bind to digoxin immune Fab is inactive and each 40mg(1 vial) binds 0.6 mg of digoxin. 

Dose: Empiric dosing 10-20 vials bolus for life-threatening toxicity 

25. Long-lived B cells were part of previous immune response and are more rapidly activated if antigen enters the body?

A. Naive B cells 

B. Memory B cells

C. T lymphocytes 

D. Cytotoxic T cells 

E. Helper T cells 

Answer: B. Memory B cells (type of B lymphocytes)

White Blood cells (Leukocytes)

A. A granulocytes (Monocytes, Lymphocytes(B & T lymphocytes)

B. Granulocytes (Neutrophils, Eosinophils, Basophils)

26. Substances that enhance the immunogenicity of an antigen or nonspecifically enhance antibody production in response to antigen?

A. Immunogens

B. Accessory Cells  

C. Adjuvant 

D. Affinity 

E. Apoptosis 

Answer: C. Adjuvant 

Immunogens are compounds that cause a specific immune response 

Accessory Cells also called effector cells help in enhancing interaction with and activation by an antigen during an adaptive immune response 

Affinity measure of the binding strength of an antibody combining site (paratope for its epitope) 

Apoptosis is also known as programmed cell death in response to certain stimuli such as cytokine or receptor-ligand binding 

27. known as programmed cell death in response to certain stimuli such as cytokine or receptor-ligand binding?

A. Immunogens

B. Accessory Cells  

C. Adjuvant 

D. Affinity 

E. Apoptosis 

Answer: E. Apoptosis 

Characterized as membrane blebbing, cell shrinkage, chromosomal DNA fragmentation