Medicinal Chemistry MCQs FOR FPGEE Exam 66

01. Which substance is degraded by COMT (Catechol-O-Methyl transferase)?
A. Epinephrine
B. Norepinephrine
C. Dopamine
D. Catechol estrogens
E. All of these

Answer. E. All of these

02. A thiophene-containing agent that blocks the synthesis of leukotrienes by inhibiting 5_ lipoxygenase is the following?
A. Zileuton
B. Acetaminophen
C. Zafirlukast
D. Montelukast


Answer: A. Zileuton


03. An agent that contains sulfonamide structure in structural formula and blocks cysLT¹  receptor thus blocking the effect of leukotrienes?
A. Zileuton
B. Acetaminophen
C. Zafirlukast
D. Ergotamine

Answer: C. Zafirlukast

04. Which of the following drug contain sulfonamide structure in the structural formula?
A. Meloxicam
B. Mefenamic acid
C. Celecoxib
D. Acetaminophen
E. None of these

Answer: C. Celecoxib


05. Para-aminophenol derivative drug is the following?
A. Meloxicam
B. Mefenamic acid
C. Celecoxib
D. Acetaminophen
E. None of these


Answer: D. Acetaminophen

06. Nabumetone is a prodrug derived from which of the following class?
A. Propionic acid derivative
B. Salicylic Acid derivatives
C. Acetic acid derivative
D. Fenamic acid derivative
E. Enolic acid derivative

Answer: C. Acetic acid derivative


07. Ketorolac is derived from which of the following class? 
A. Propionic acid derivative
B. Salicylic Acid derivatives
C. Acetic acid derivative
D. Fenamic acid derivative
E. Enolic acid derivative


Answer: A. Propionic acid derivative

08. Which of the following is a Sulphamoyl Derivative diuretic drug?
A. Ethacrynic Acid
B. Hydrochlorothiazide
C. Chlorthalidone
D. Bumetanide
E. Metolazone


Answer: E. Bumetanide

09. Which of the following drug is Phenoxy acetic acid derivative diuretic?
A. Benzthiazide
B. Chlorthalidone
C. Ethacrynic acid
D. Torasemide
E. Furosemide

Answer: C. Ethacrynic acid 

10. A fenamic acid derivative of Nonsteroidal anti-inflammatory drugs also called?
A. Acetic acid
B. Oxicam
C. Propionic acid
D. Salicylates
E. N-arylanthranilic acids


Answer: E. N-arylanthranilic acids


11. An enolic acid derivative of Nonsteroidal anti-inflammatory drugs also called?
A. Acetic acid
B. Oxicam derivative
C. Propionic acid
D. Salicylates
E. N-arylanthranilic acids

Answer: B. Oxicam derivative

12. Which of the following drug is a derivative of N- arylanthranilic acid?
A. Diflunisal
B. Etodolac
C. ketorolac
D. Mefenamic Acid
E. Piroxicam

Answer: D. Mefenamic acid

13. Which of the following drug is a derivative of Enolic acid?
A. Diflunisal
B. Etodolac
C. ketorolac
D. Mefenamic Acid
E. Piroxicam

Answer: E. Piroxicam

14. Which of the following drug is a derivative of Acetic acid?
A. Diflunisal
B. Etodolac
C. ketorolac
D. Mefenamic Acid
E. Piroxicam

Answer: B. Etodolac

 
15. Which of the following drug is a derivative of Propionic acid?
A. Diflunisal
B. Etodolac
C. ketorolac
D. Mefenamic Acid
E. Piroxicam

Answer: C. Ketorolac

16. Which of the following drug is a derivative of Fenamic acid?
A. Diflunisal
B. Etodolac
C. ketorolac
D. Mefenamic Acid
E. Piroxicam

Answer: D. Mefenamic Acid

17. Which of the following drug is the Propionic acid derivative NSAID?
A. Aspirin
B. Naproxen
C. Mefenamic Acid
D. Diclofenac
E. Piroxicam

Answer:  B. Naproxen

18. Which of the following drug is Pyrazolone Derivative NSAID?
A. Indomethacin
B. Nimesulide
C. Phenylbutazone
D. Ketorolac
E. Diclofenac


Answer: C. Phenylbutazone

19. Prostaglandin is derived from prostanoic acid, prostanoic acid contains 20 carbon fatty acids, how many carbons rings are in the structural formula of prostanoic acid?
A. 6 carbon ring
B. 5 carbon ring
C. 4 carbon ring
D. 3 carbon ring
E. 2 carbon ring

Answer: B. 5 carbon ring

20. Which of the following drug is a derivative of salicylic acid?
A. Diflunisal
B. Etodolac
C. ketorolac
D. Mefenamic Acid
E. Piroxicam

Answer: A. Diflunisal