MEDICOLOGY: PHARMACOLOGY QUIZZES 09 | Multiple Choice Questions| Medical Exam Preparations

Sunday, January 30, 2022

PHARMACOLOGY QUIZZES 09 | Multiple Choice Questions| Medical Exam Preparations

01. Angiotensin II receptor blocker drug?
A. Hydralazine
B. Ramipril
C. Lisinopril
D. Bisoprol
E. Valsartan

Answer: E. Valsartan

02. Sulfonylurea is one of the following drugs?
A. Metformin
B. Glyburide
C. Acarbose
D. Pioglitazone
E. Miglitol

Answer: B. Glyburide

03. All of the following drugs are 1st generation sulfonylureas except?
A. Tolbutamide
B. Glimepiride
C. Tolazamide
D. Chlorpropamide

Answer: B. Glimepiride

04. Sotalol belongs to one of the following Antiarrhythmic drugs?

Answer: C. CLASS III 

05. Which one of the following drugs is a CLASS II Antiarrhythmic drug?
A. Disopyramide 
B. Esmolol 
C. Amiodarone
D. Diltiazem

Answer: B. Esmolol

06. A drug that is a part of Aminoglycosides is following?
A. Gentamicin 
B. Amikacin
C. Cefdinir
D. A & B
E. All of these 

Answer: D. A & B

07. Which one of the following drugs causes inhibition of HIV protease?
A. Zanamivir 
B. Nelfinavir 
C. Amantadine
D. Ribavirin 
E. A & B
F. A & C

Answer: B. Nelfinavir

08. Which one of the following drugs belongs to 1st generation Cephalosporins?
A. Cefaclor
B. Cephalexin
C. Cefdinir
D. Cefepime

Answer: B. Cephalexin

09. Which one of the following drugs is a first-generation sulfonylurea?
A. Chlorpropamide
B. Tolazamide 
C. Tolbutamide
D. All of above

Answer: All of the above

10. Which one of the following drugs is a 2nd generation Cephalosporin?
A. Cefuroxime
B. Cefadroxil
C. Cefdinir
D. Cefepime

Answer: A. Cefuroxime

11. 30 years of age, has been treated with several autonomic drugs for 4 weeks. Due to toxicity signs, he is admitted to the hospital. Which of the following sign would distinguish between an overdose of a ganglion blocker versus a muscarinic blocker?
a) Blurred vision
b) Dry mouth
c) Mydriasis
d) Postural hypotension
e) Tachycardia 

Answer: D) Postural hypotension

12. A drug that Increases the cell permeability allowing more Flucytosine (5-FC) to penetrate the cell?
A. Ketoconazole
B. Amphotericin B
C. Nystatin
D. Caspofungin

Answer: B. Amphotericin B (polyene antifungal)
Flucytosine and Amphotericin B are synergistic drugs.
Amphotericin B naturally occurs produced from streptomyces nodosus. 
MOA: Amphotericin B interact hydrophobically with ergosterol in the fungal cell membrane forming pores (gaps, spaces) in the lipid bilayer membrane these pores causes loss of potassium and other molecules causing cell death. 

13. Which one of the following drugs inhibit the enzyme phosphodiesterase which inactivate the cAMP?
A. Dipyridamole
B. Argatroban
C. Aminocaproic acid
D. Warfarin

Answer: A. Dipyridamole

14. Mechanism of action of repaglinide?
A. GLP-1 agonist 
B. Insulin secretagogue
C. DPP-IV inhibitor
D. A-glucosidase inhibitor
E. Insulin sensitiser 

Answer: B. Insulin secretagogue

15. Following has a longest half life?
A. Naproxen 
B. Ketoprofen
C. Flurbiprofen
D. Oxaprozin
E. Fenoprofen

Answer: D. Oxaprozin

16. A drug that acts as a viral uncoating inhibitor is one of the following?
A. Bumetanide
B. Rimantadine  
C. Magnesium hydroxide  
D. Tiludronate
E. A & B

Answer: Rimantadine

17. Polyuria, Polydipsia, polyphagia, weight loss are symptoms of the following disease?
A. Diabetes Mellitus
B. Amyloidosis
C. Angalman Disorder
D. Polycystic ovary disease

Answer: A. Diabetes Mellitus

18. Nasopharyngitis is the adverse effect of one of the following drugs?
A. Acarbose
B. Rosiglitazone
C. Troglitazone
D. Metformin
E. Sitagliptin

Answer: E. Sitagliptin

19. Intravenous ethanol 10% is used in the toxicity of Ethylene glycol & methanol when one of the following drugs is not available to overcome the toxicity of Ethylene glycol & methanol?
A. Atropine
B. Piroxicam
C. Fomepizole
D. Pyridostigmine

Answer: C. Fomepizole Same dose: 15mg/kg IV bolus then smaller repeat doses may be necessary 
Ethanol 10% Dose: Loading dose:10ml/kg IV or orally; maintenance dose : 1-2ml/kg/h IV infusion or orally 

20. Which one of the following drugs is a Inducer of the P-GP (glycoprotein) efflux pumps?
A. Erythromycin 
B. Digoxin 
C. Amiodarone 
D. Rifampin 
E. All of the above 

Answer: D. Rifampin 

21. Tumor markers are biochemical indicators of the presence of neoplastic proliferation detected in serum, plasma or other body fluids. Carcinoembryonic antigen (CEA) is used for?
A. Colorectal cancer 
B. Hepatoblastoma
C. Hepatocellular carcinoma 
D. Prostate cancer 
E. All of the above 

Answer: A. Colorectal cancer 

22. A drug that enters the fungal cell via cytosine specific permease with a adverse effect of reversible neutropenia?
A. Amphotericin B
B. Flucytosine
C. Fluconazole
D. Griseofulvin 

Answer: B. Flucytosine (synthetic pyrimidine used in combination with Amphotericin B to treat systemic mycoses , meningitis and with itraconazole to treat chromoblastomycosis. 
5-FC ↔️ 5-FU ↔️ 5-FdUMP ↔️ dUMP ↔️ dTMP ↔️ DNA synthesis. 5-FC inhibit thymidylate synthase that convert dUMP to dTMP thus leading to disruption in DNA synthesis.

23. Which antifungal agent is MOST likely to cause renal
A. Fluconazole
B. Amphotericin B
C. Itraconazole
D. Posaconazole

Answer: B. Amphotericin B 
B. Amphotericin B a the best choice since, nehrotoxiclly is commonly associated with this medication Although the dose of fluconazole must be adjusted for renal insufficiency, it is not associated with causing nephrotoxicity. iraconazole and posaconazole are melabolized by the liver and are not associated with nephrotoxicity.

24. A 55-year-old woman presents to the hospital with
shortness of breath, fever, and malaise. She has a history of breast cancer and is receiving chemotherapy. Her chest x-ray shows pneumonia, and respiratory cultures are positive for Aspergillus fumigatus. Which is the MOST appropriate choice for treatment?
A. Voriconazole
B. Fluconazole
C. Flucytosine
D. Ketoconazole

Answer: A. Voriconazole
A. Voriconazole is the drug of choice by aspergillosis. Studies have found it to be superior to other regimens including amphotericin B. Fluconazole, Flucytosine, and ketoconazole do not have reliable in vitro activity  and are therefore not recommended.

25. Which antifungal agent should be avoided in patients
with evidence of ventricular dysfunction?
A. Micafungin
B. Itraconazole
C. Terbinafine
D. Posaconazole

Answer: B. Itraconazole
B. There is a black box warning that warns against the use of itraconazole in patients with evidence of ventricular dysfunction, including patients with heart failure.

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