PHARMACOLOGY QUIZZES 28 | Multiple Choice Questions| Medical Exam Preparations

01. Which of the following drug is penicillin?
A. Dicloxacillin
B. Amiodarone 
C. Amiloride
D. Spironolactone 
E. Cefadroxil 

Answer: A. Dicloxacillin

02. A drug that belongs to Cephalosporins is one of the following?
A. Niacin
B. Chlorthalidone
C. Ampicillin 
D. Mannitol
E. Cephalexin

Answer: E. Cephalexin

03. A drug that belongs to Carbapenems is one of the following?
A. Meropenem
B. Furosemide 
C. Cefazolin 
D. Torsemide
E. Cephalexin 

Answer: A. Meropenem

04. Which one of the following drugs is an aminoglycoside drug?
A. Linezolid
B. Clindamycin
C. Clarithromycin
D. Gentamicin


Answer: D. Gentamicin

05. Which one of the following drugs is an inhibitor of nucleic acid function or synthesis?
A. Fluoroquinolone
B. Tetracycline
C. Isoniazid
D. Sulfonamides

Answer: A. Fluoroquinolone

06. Which one of the following drugs is an inhibitor of cell wall synthesis?
A. Tetracycline
B. Rifampin
C. Vancomycin
D. Amphotericin B

Answer: C. Vancomycin

07. The major reason why carbidopa is of value in parkinsonism is that the compound 
(A) Crosses the blood-brain barrier 
(B) Inhibits monoamine oxidase type A 
(C) Inhibits aromatic L-amino acid decarboxylase 
(D) Is converted to the false neurotransmitter, carbidopamine 
(E) Inhibits monoamine oxidase type B 

Answer: C. Inhibits aromatic L-amino acid decarboxylase

08. As the physician who is prescribing levodopa, you will note that the drug 
(A) Has less severe behavioral side effects if given with carbidopa 
(B) Fluctuates in its effectiveness with increasing frequency as treatment continues 
(C) Effectively antagonizes the extrapyramidal adverse effects of antipsychotic drugs 
(D) Has anticancer effects in patients with melanoma 
(E) Causes irreversible tardive dyskinesias 


Answer: (B) Fluctuates in its effectiveness with increasing frequency as treatment continues 
Explanation:
this is called the "on-off phenomenon" .. parkinsonism is a progressive degenerative disease of dopaminergic neurons. as the disease progresses there is less availability of viable dopaminergic nerve terminals from where levodopa is processed and released. so the relief from symptoms is then due to the time-to-time release of dopamine from these neurons which gives fluctuation in response. imagine you have a slow water supply and you build 5 water tanks on your roof to store water, then one by one you break those tanks the storage capacity of water decreases ultimately, say, you even damage the last tank too, now you are dependent on the slow water supply only, let that water supply be Levodopa which is processed in those tanks (the viable dopaminergic nerve terminals) .. moreover due to constant stimulation of postsynaptic dopaminergic receptors, there is also down-regulation or at least desensitization of those receptors, which also contributes to this phenomenon.

09. Which one of the following drugs is a nucleoside reverse transcriptase inhibitor?

A. Abacavir
B. Saquinavir
C. Nevirapine
D. Raltegravir

Answer: A. Abacavir

10. Efavirenz belongs to the class of following drugs?

A. Antiviral 
B. Antipyretic 
C. Antiprotozoal
D. Antifungal  
E. Anti-malaria 

Answer: A.  Antiviral

11. Following is  metabolic disorder characterized by deposits of monosodium urates in joints & cartilage
A. diabetes
B. rehumtoid arrthritis
C. gout
D. hypertension 

Answer: C. Gout

12. Misoprostol is a?
a. pge1 analog
b. pge2 analog
c. pg antagonist
d. antiprogestin


Answer: a. pge1 analog


13. Among the following beta-blockers, ALL are appropriate for its use in Angina except:
a. Nebivolol
b. esmolol
c. sotalol
d. carvedilol
e. all of the above (none are appropriate)


Answer: e. all of the above (none are appropriate)


14. Multiple antibiotic resistance is transferred via :
a. transduction
b. conjugation
c. Mutations
d. Transformation

Answer: b. conjugation

15. The concentration of drug required to produce 50% of maximum efficacy is denoted as:

a) EC50
b) ED50
c) LD50
d) TD50
e) KD50


Answer: A. EC50

16. At gram doses, a drug strongly inhibits lipolysis in adipose tissues is following?
A. Fenofibrate
B. Cholestyramine
C. Gemfibrozil
D. Niacin 
E. Lovastatin

Answer: D. Niacin 
 

17. Drug interactions may be classed as follows?

A. pharmacokinetic interactions
B. pharmacodynamic interactions
C. pharmaceutical interactions
D. A & B
E. All of the above 

Answer: E. All of the above

18. Bethanechol is contraindicated for use in patients with

a) Glaucoma
b) Myasthenia gravis
c) Peptic ulcers
d) Postoperative non-obstructive urinary retention
e) Postoperative paralytic ileus


Answer: c) Peptic ulcers

19. Following diuretics block Na/K/Cl transporter in renal loop of henle & block aldosterone receptor in collecting tubule.
A. Thiazide
B. potassium sparing
C. osmotic
D. loop diuretic
E. carbonic anhydrase 

Answer: D. Loop Diuretics

20. Every 6 hours dose of Aspirin for adults should be administered as needed is following?
A. 160 mg
B. 400 to 480 mg
C. 325 to 650 mg
D. 650 to 1000 mg
E.  1600 mg

Answer: D. 650 to 1000 mg

21. Intracranial hemorrhage is the major toxicity and concern of the following drugs?
A. Ibandronate
B. Zanamivir 
C. Capecitabine
D. Tipranavir
E. Naftifine

Answer: D. Tipranavir   

22. Fatty liver degeneration accompanied by encephalopathy called Reye's syndrome is caused by?
A. Celecoxib  
B. Aspirin 
C. Acetaminophen 
D. Naproxen 
E. Piroxicam

Answer: B. Aspirin

23. Exercise intolerance and fatigue is an adverse effect linked with one of the following drugs?
A. Prazosin
B. Phentolamine
C. Diltiazam
D. Atenolol
E. Both C & D

Answer: D. Atenolol

24. Which one of the following drugs is not an analog of purine and pyrimidine?
A. Acyclovir 
B. Foscarnet
C. Cidofovir
D. Gencyclovir
E. Penciclovir

Answer: B. Foscarnet

25. Which one of the following is the neurotransmitter at postganglionic neurons (sympathetic) to the thermoregulatory sweat glands?
A. Epinephrine
B. Norepinephrine
C. Acetylcholine
D. Dopamine
E. Isoproterenol

Answer: C. Acetylcholine

Use of Acetylcholine as a Neurotransmitter 

01. The preganglionic fibers terminating in adrenal medulla

02. Autonomic ganglia of both Sympathetic and parasympathetic 

03. Postganglionic sympathetic division of sweat glands 

Note: cholinergic neurons innervate the muscle of somatic system.

26. Which one of the following is the primary neurotransmitter at the somatic ( voluntary) neuromuscular junction of skeletal muscle?
A. Epinephrine
B. Norepinephrine
C. Acetylcholine
D. Dopamine
E. Isoproterenol

Answer: C. Acetylcholine

27. A drug that increases the risk of Reye's syndrome is following?
A. Acetaminophen 
B. Diflunisal 
C. Aspirin 
D. A & B
E. B & C

Answer: C. Aspirin 

28. Salicylates Potentiate the effects of following drugs as a drug interaction?
A. Anticoagulants
B. Thrombolytic agents
C. Hypoglycaemic (anti-inflammatory doses)
D. A & B
E. All of the above 

Answer: E. All of these 

29. Potentially fatal hepatitis is the most severe side effect of?
A. Isoniazid
B. Pyrazinamide
C. Ethambutol
D. Streptomycin

Answer:  A. Isoniazid
Because toxic metabolites monomethylhydrazine formed during the metabolism of Isoniazid.

30. One of the following statements about the therapeutic use of Labetalol and Carvedilol is wrong?
A. Reversible Beta antagonist
B. Produce Peripheral vasodilation
C. Reduce blood glucose levels
D. Decrease lipid peroxidation
E. Labetalol used as an alternative to methyldopa in pregnancy

Answer: C. Reduce blood glucose levels