01. Which one of the following drugs is a beta-blocker drug?
A. Lisinopril
B. Propranolol
C. Furosemide
D. Verapamil
Answer: B. Propranolol
02. Which of the following drug is a Calcium Channel Blocker?
A. Captopril
B. Atenolol
C. Diltiazem
D. Furosemide
Answer: C. Diltiazem
03. Which of the following drug is a Diuretic drug?
A. Captopril
B. Atenolol
C. Diltiazem
D. Furosemide
Answer: C. D. Furosemide
A. Lisinopril
B. Propranolol
C. Furosemide
D. Verapamil
Answer: B. Propranolol
02. Which of the following drug is a Calcium Channel Blocker?
A. Captopril
B. Atenolol
C. Diltiazem
D. Furosemide
Answer: C. Diltiazem
03. Which of the following drug is a Diuretic drug?
A. Captopril
B. Atenolol
C. Diltiazem
D. Furosemide
Answer: C. D. Furosemide
04. Which one of the following drugs is a Potassium-sparing Diuretics drug?
A. Chlorthalidone
B. Bumetanide
C. Amiloride
D. Acetazolamide
Answer: C. Amiloride
05. Cholesterol absorption antihyperlipidemic drug in the following list?
A. Colestipol
B. Fenofibrate
C. Simvastatin
D. Ezitimibe
E. Gemfibrozil
Answer: D. Ezetimibe
06. Bile acid sequestrant antihyperlipidemic drug in the following list?
A. Colesevelam
B. Fenofibrate
C. Simvastatin
D. Ezetimibe
E. Gemfibrozil
Answer: A. Colesevelam
07. Glipizide belongs to which of the following diabetic agents?
A. Sulfonylureas
B. Meglitinide analogs
C. Biguanides Glitazones
D. Alpha glucosidase inhibitor
E. Thiazolidinediones
Answer: A. Sulfonylureas (ADRs: Weight gain, hypoglycaemia)
Answer: A. Gemcitabine
09. Which of the following drugs is used for respiratory virus infections?
A. Ibandronate
B. Amantadine
C. Capecitabine
D. Miconazole
E. Naftifine
Answer: B. Amantadine
14. "Pericarditis–myocarditis syndrome" is caused by which of the following cytotoxic agent??
A. Cisplatin
B. Busulfan
C. Streptozotocin
D. Vinblastine
E. Doxorubicin
F. Tamoxifen
Answer: E. Doxorubicin
15. Which one of the following agents will increase pulse pressure?
a) Adrenaline
b) Dopamine
c) Isoprenaline
d) Phenylephrine
e) Salbutamol
Answer: a) Adrenaline
The answer is A, Epinephrine has a positive ionotropic and chronotropic effect on the heart because of its beta 1-adrenergic activity. It also has an alpha-1 adrenergic activity that causes vasoconstriction in the vascular beds. These actions result in a rise in systolic blood pressure. Epinephrine also has beta 2-adrenergic activity, which causes vasodilation in skeletal muscle. Because of this latter effect, total peripheral resistance can fall, resulting in a drop in diastolic pressure, particularly at low doses of epinephrine. Pulse pressure = systolic BP – diastolic BP, so Epinephrine increases pulse pressure caused by the widening gap between systolic and diastolic BP.
Katzung has mentioned that Isoprenaline also decreases pulse pressure due to its beta 1 and beta 2 actions, however among the two adrenaline is slightly more likely to increase pulse pressure because it can further increase systolic BP via its alpha-1 agonist effect.
A. Chlorthalidone
B. Bumetanide
C. Amiloride
D. Acetazolamide
Answer: C. Amiloride
05. Cholesterol absorption antihyperlipidemic drug in the following list?
A. Colestipol
B. Fenofibrate
C. Simvastatin
D. Ezitimibe
E. Gemfibrozil
Answer: D. Ezetimibe
06. Bile acid sequestrant antihyperlipidemic drug in the following list?
A. Colesevelam
B. Fenofibrate
C. Simvastatin
D. Ezetimibe
E. Gemfibrozil
Answer: A. Colesevelam
07. Glipizide belongs to which of the following diabetic agents?
A. Sulfonylureas
B. Meglitinide analogs
C. Biguanides Glitazones
D. Alpha glucosidase inhibitor
E. Thiazolidinediones
Answer: A. Sulfonylureas (ADRs: Weight gain, hypoglycaemia)
08. Which one of the following drugs belongs to ANTIMETABOLITES drugs for Cancer?
A. Gemcitabine
B. Capreomycin
C. Lamivudine
D. Ezetimibe
E. Indanyl carbenicillin
A. Gemcitabine
B. Capreomycin
C. Lamivudine
D. Ezetimibe
E. Indanyl carbenicillin
Answer: A. Gemcitabine
09. Which of the following drugs is used for respiratory virus infections?
A. Ibandronate
B. Amantadine
C. Capecitabine
D. Miconazole
E. Naftifine
Answer: B. Amantadine
10. Which one of the following drugs belongs to ANTIMETABOLITES drugs for Cancer?
A. 6-Mercaptopurine
B. Capreomycin
C. Lamivudine
D. Ezetimibe
E. Indanyl carbenicillin
Answer: A. 6-Mercaptopurine
A. 6-Mercaptopurine
B. Capreomycin
C. Lamivudine
D. Ezetimibe
E. Indanyl carbenicillin
Answer: A. 6-Mercaptopurine
11. Which of the following drugs is neuraminidase inhibitor drug?
A. Ibandronate
B. Oseltamivir
C. Capecitabine
D. Miconazole
E. Naftifine
Answer: B. Oseltamivir
A. Ibandronate
B. Oseltamivir
C. Capecitabine
D. Miconazole
E. Naftifine
Answer: B. Oseltamivir
12. A drug that has a positive inotropic effect on the myocardium because it stimulates 𝛃1 receptor?
A. Dobutamine
B. Clonidine
C. Phenylephrine
D. Terbutaline
E. Dipivefrin
Answer: A. Dobutamine
A. Dobutamine
B. Clonidine
C. Phenylephrine
D. Terbutaline
E. Dipivefrin
Answer: A. Dobutamine
13. A drug that inhibits cytokine-stimulated cell proliferation is following?
A. Azathioprine
B. Cyclosporine
C. Basiliximab
D. Sirolimus
Answer: D. Sirolimus
A. Azathioprine
B. Cyclosporine
C. Basiliximab
D. Sirolimus
Answer: D. Sirolimus
14. "Pericarditis–myocarditis syndrome" is caused by which of the following cytotoxic agent??
A. Cisplatin
B. Busulfan
C. Streptozotocin
D. Vinblastine
E. Doxorubicin
F. Tamoxifen
Answer: E. Doxorubicin
15. Which one of the following agents will increase pulse pressure?
a) Adrenaline
b) Dopamine
c) Isoprenaline
d) Phenylephrine
e) Salbutamol
Answer: a) Adrenaline
The answer is A, Epinephrine has a positive ionotropic and chronotropic effect on the heart because of its beta 1-adrenergic activity. It also has an alpha-1 adrenergic activity that causes vasoconstriction in the vascular beds. These actions result in a rise in systolic blood pressure. Epinephrine also has beta 2-adrenergic activity, which causes vasodilation in skeletal muscle. Because of this latter effect, total peripheral resistance can fall, resulting in a drop in diastolic pressure, particularly at low doses of epinephrine. Pulse pressure = systolic BP – diastolic BP, so Epinephrine increases pulse pressure caused by the widening gap between systolic and diastolic BP.
Katzung has mentioned that Isoprenaline also decreases pulse pressure due to its beta 1 and beta 2 actions, however among the two adrenaline is slightly more likely to increase pulse pressure because it can further increase systolic BP via its alpha-1 agonist effect.
16. St. John’s wort may induce CYP3A4 isoenzymes and decrease cyclosporine to subtherapeutic levels. Type of interaction?
A. Drug-Drug
B. Drug-Chemical
C. Drug-Food
D. Drug-Herbal
E. Drug-Laboratory
Answer: D. Drug-Herbal
A. Drug-Drug
B. Drug-Chemical
C. Drug-Food
D. Drug-Herbal
E. Drug-Laboratory
Answer: D. Drug-Herbal
17. Which one of the following receptor types is linked with Pupillary Dilation of smooth muscle cells in the eyes?
A. Alpha-1
B. Beta-1
C. Beta-2
D. M³ receptor
E. M¹ receptor
Answer: Alpha-1
18. The synaptic vesicle of an adrenergic neuron contains all of the following except?
A. Dopamine
B. Norepinephrine
C. Adenosine Triphosphate
D. Catechol-O-methyltransferase
E. Beta-hydroxylase
Answer: D. Catechol-O-methyltransferase
A. Dopamine
B. Norepinephrine
C. Adenosine Triphosphate
D. Catechol-O-methyltransferase
E. Beta-hydroxylase
Answer: D. Catechol-O-methyltransferase
19. Which one of the following statements about the use of Celecoxib is incorrect?
A. Don't increase bleeding time
B. Increase myocardial infarction
C. More GI irritation than aspirin
D. Used for osteoarthritis
E. Reversible inhibitor
Answer: C. More GI irritation than aspirin
A. Don't increase bleeding time
B. Increase myocardial infarction
C. More GI irritation than aspirin
D. Used for osteoarthritis
E. Reversible inhibitor
Answer: C. More GI irritation than aspirin
20. A patient comes to the emergency ward with recent organophosphorus compound poisoning.The symptom not shown in this patient would be:
a) Bronchodilatationb) Diarrhea
c) Increased lacrimation
d) Increased salivation
e) Muscle Weakness
Answer: a) Bronchodilatation
21. Exaggerated IgE mediated response causes Atopic diseases e.g asthma rhinitis, are what type of hypersensitivity?
A. Type I
B. Type II
C. Type III
D. Type IV
Answer: A. Type I
Hypersensitivity: exaggerated immune response that is harmful to the individual.
Type I hypersensitivity: also known as immediate hypersensitivity or allergy and include atopy e.g allergic rhinitis or hay fever, food allergies, eczema, Asthma and anaphylaxis.
Caused by elevated IgE production, IgE being bound by Fc epsilon receptor on the surface of mast cells this IgE bound to mast cells causes release of others mediators e.g histamine.
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