A. Selective estrogen modulator (SERM)
B. Estrogen antagonist in bone and endometrium
C. Estrogen Antagonist in breast tissue
D. Treat estrogen receptor positive breast cancer
E. Prevent breast cancer
Answer: B. Estrogen antagonist in bone and endometrium
Tamoxifen is estrogen antagonist in breast tissue and agonist in other tissues such as bone and endometrium
02. Which of the following statements about Tamoxifen is wrong?
A. Compete estrogen to bind with estrogen receptor
B. Inhibit estrogen induced growth of breast cancer
C. Deplete estrogen receptors ( down regulation)
D. Suppress growth factors and natural hormones
E. Estrogen antagonist in bone and endometrium
Answer: E. Estrogen antagonist in bone and endometrium
03. Which of the following is the common adverse effect of steroid hormones and their antagonists?
A. Hypertension
B. Dry cough
C. Diarrhoea
D. Hot flashes
E. Hypocalcemia
Answer: D. Hot flashes
04. A drug bind to estrogen receptor and causes estrogen recpetor down regulation are following?
A. Fulvestrant
B. Tamoxifen
C. Raloxifene
D. B & C
E. All of the above
Answer: E. All of the above
05. Which of the following drugs responsible for inhibition of synthesis of estrogen from androstenedione?
A. Tamoxifen
B. Aromatase inhibitors
C. Antiandrogens
D. Platinum coordination complexes
E. Topoisomerase inhibitors
Answer: B. Aromatase Inhibitors
Anstrozole, letrozole, Exemestane
06. Which of the following drugs causes irreversible inhibition of synthesis of estrogen from androstenedione?
A. Tamoxifen
B. Raloxifene
C. Antiandrogens
D. Platinum coordination complexes
E. Exemestane
Answer: E. Exemestane
07. Which of the following drugs is steroidal irreversible inhibitors of synthesis of estrogen from androstenedione?
A. Tamoxifen
B. Anstrozole
C. Antiandrogens
D. Platinum coordination complexes
E. Raloxifene
Answer: B. Anstrozole
08. Which of the following drugs is nonsteroidal inhibitor of synthesis of estrogen from androstenedione?
A. Tamoxifen
B. Anstrozole
C. Antiandrogens
D. Platinum coordination complexes
E. Exemestane
Answer: B. Anstrozole
Along with letrozole
09. Which of the following drugs occupy the GnRH receptor in the pituitary to desensitise it leading to inhibit the release of FSH and LH?
A. Leuprolide
B. Goserelin
C. Triptorelin
D. A & B
E. All of the above
Answer: E. All of the above
Note: GnRH is secreted by hypothalamus and stimulates the anterior pituitary to secrete the gonadotropin hormones that is luteinizing hormone (LH) and Follicle stimulating hormone (FSH). LH is the primary stimulus for secretion of testosterone by the testes while FSH stimulate the secretion of estrogen. These drugs occupy the GnRH receptor present in the anterior pituitary.
10. Which of the following drugs occupy the GnRH receptor in the pituitary to desensitise it leading to inhibit the release of FSH and LH?
A. Leuprolide
B. Tamoxifen
C. Anastrozole
D. A & B
E. All of the above
Answer: A. Leuprolide
Along with Goserelin and Triptorelin
11. A drug that competes with the natural hormone for binding to the androgen receptor and prevent its action in prostate?
A. Leuprolide
B. Tamoxifen
C. Anastrozole
D. Flutamide
E. All of the above
Answer: D. Flutamide
Along with Nilutamise, Biculutamide, Enzalutamide oral anti androgens.
12. A patient was mistakenly administered vincristine instead of cytarabine intrathecally. What is the likely outcome of this drug error?
A. Neuropathy
B. Renal failure
C. Hearing loss
D. Death
Answer: D. Death
Vincristine is fatal if given intathecally.
13. Which of the following drug causes death when administered intrathecally?
A. Vincristine
B. Cytarabine
C. Cisplatin
D. Vinblastine
E. Vinorelbine
Answer: A. Vincristine
14. Which of the following drugs treatment require vigorously hydration when used?
A. Cisplatin
B. Carboplatin
C. Oxaliplatin
D. A & B
E. All of the above
Answer: A. Cisplatin
Hydration is recommended to induce diureses and reduce the concentration of Cisplatin in kidney. Because this drug causes nephrotoxicity involving the distal convoluted tubule and collecting ducts.
Following drugs belongs to platinum coordination complexes?
A. Cisplatin
B. Carboplatin
C. Oxaliplatin
15. Which of the following drugs causes most Ototoxicity with high frequency hearing loss and tinnitus?
A. Cisplatin
B. Carboplatin
C. Oxaliplatin
D. A & B
E. All of these
Answer: A. Cisplatin
16. A drug having high incidence of nausea and vomiting after administration so premedication with antiemetic agent is required?
A. Cisplatin
B. Carboplatin
C. Oxaliplatin
D. A & B
E. All of these
Answer: A. Cisplatin
17. Which chemotherapy drug can cause nephrotoxicity, neurotoxicity, Ototoxicity, electrolyte abnormalities and severe nausea and vomiting?
A. Cisplatin
B. Etoposide
C. Oxaliplatin
D. Cyclophosphamide
Answer: A. Cisplatin
18. Development of signs of which condition should be monitored in patients receiving chemotherapy with ifosfamide?
A. Cardio toxicity
B. Rash
C. Neurotoxicity
D. Hand foot syndrome
Answer: C. Neurotoxicity
19. Hand foot syndrome is the adverse effect of following drug?
A. Cisplatin
B. Carboplatin
C. Oxaliplatin
D. 5-FU and darivatives
E. Vincristine
Answer: D. 5-FU and derivative
20. A patient is about to begin therapy with doxorubicin and cyclophosphamide. Which test should be ordered for baseline assessment before treatment?
A. Baseline PFTs
B. Baseline stress test
C. Baseline echocardiogram
D. Baseline urinalysis
Answer: C. Baseline echocardiogram
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