01. Tumor markers are biochemical indicators of the presence of neoplastic proliferation detected in serum, plasma or other body fluids. Alpha-Fetoprotein is used for?
A. Colorectal cancer
B. Hepatoblastoma
C. Hepatocellular carcinoma
D. Prostate cancer
E. A & B
F. B & C
Answer: F. B & C
02. Which one of the following drugs is potent myelosuppressant microtubule inhibitor drug?
A. Vincristine
B. Vinblastine
C. Vinorelbine
D. Paclitaxel
E. Docetaxel
Answer: B. Vinblastine
A, B, C drugs are derived from periwinkle plant, Vinca rosea so called vinca alkaloids. D & E are semisynthetic drugs.
03. Which one of the following drugs is less neurotoxic naturally synthesised microtubule inhibitor drug?
A. Vincristine
B. Vinblastine
C. Vinorelbine
D. Paclitaxel
E. Docetaxel
Answer: C. Vinorelbine
A, B, C drugs are derived from periwinkle plant, Vinca rosea so called vinca alkaloids. D & E are semisynthetic drugs.
04. Which of the following drugs can cause hyperuricemia due to oxidation of purines that are from fragmenting DNA molecules?
A. Vincristine
B. Vinblastine
C. Vinorelbine
D. A & B
E. All of the above
Answer: E. All of the above
A, B, C drugs are derived from periwinkle plant, Vinca rosea so called vinca alkaloids.
05. A drug that promotes polymerisation and stabilisation of the polymer rather than disassembly?
A. Vincristine
B. Vinblastine
C. Vinorelbine
D. Paclitaxel
E. All of the above
Answer: D. Paclitaxel
Docetaxel and Paclitaxel promote stabilisation. While vinca alkaloids block the ability of tubulin to form microtubules.
06. The phase in which the cell devides into two daughter cells?
A. M Phase
B. G1 Phase
C. S Phase
D. G2 Phase
E. G0 Phase
Answer: A. M phase
07. The phase in RNA and enzymes topoisomeease I and Topoisomerase II are produced?
A. M Phase
B. G1 Phase
C. S Phase
D. G2 Phase
E. G0 Phase
Answer: D. G2 Phase
08. The phase in which the cell is not committed to division?
A. M Phase
B. G1 Phase
C. S Phase
D. G2 Phase
E. G0 Phase
Answer: E. G0 Phase
09. The phase in which DNA synthesis and replication occurs?
A. M Phase
B. G1 Phase
C. S Phase
D. G2 Phase
E. G0 Phase
Answer: C. S Phase
10. The phase in which the RNA and the protein required for the specialized function of the cell are synthesised in preparation for DNA synthesis?
A. M Phase
B. G1 Phase
C. S Phase
D. G2 Phase
E. G0 Phase
Answer: B. G1 Phase
11. Adverse effects of methotrexate can be reversed by administering following drug?
A. Allopurinol
B. Leucovorin
C. Cytarabine
D. 6-mercaptopurine
E. Gemcitabine
Answer: B. Leucovorin
Leucovorin reversed the inhibition of dihydrofolate reductase (DHFR).
12. Which of the following anti tumour antibiotics drugs is cell cycle specific?
A. Doxorubicin
B. Daunorubicin
C. Idarubicin
D. Mitoxantrone
E. Bleomycin
Answer: E. Bleomycin
13. Which of the following anti tumour drugs are anthracyclines antibiotics except?
A. Doxorubicin
B. Daunorubicin
C. Idarubicin
D. Mitoxantrone
E. Bleomycin
Answer: E. Bleomycin
All others are anthracyclines antibiotics, these drugs can induce membrane lipid peroxidation, DNA strand scission, and direct oxidation of purines and pyrimidines bases, thiols and amines.
14. Which of the following anti tumour antibiotics drugs don't cause red coloration of urine?
A. Doxorubicin
B. Daunorubicin
C. Idarubicin
D. Epirubicin
E. Bleomycin
Answer: E. Bleomycin
All others cause red coloration of urine due to dark red color of the anthracyclines drugs.
15. Which of the following anti tumour antibiotics drugs are inactivated in the GI tract?
A. Doxorubicin
B. Daunorubicin
C. Idarubicin
D. A & B
E. All of these
Answer: E. All of these
Along with other anthracyclines drugs.
16. Which of the following drugs anti tumor antibiotics drugs is less cardio toxic than others?
A. Doxorubicin
B. Daunorubicin
C. Liposomal Doxorubicin
D. Idararubicin
E. Epirubicin
Answer: C. Liposomal Doxorubicin
17. Which of the following drugs is selective estrogen modulator (SERM)?
A. Tamoxifen
B. Anstrozole
C. Exemestane
D. Leuprolide
E. Flutamide
Answer: A. Tamoxifen
Tamoxifen is an antagonist in breast tissue and an agonist in other tissues like bone and the endometrium.
18. Which of the following drugs competes with estrogen for binding to estrogen receptors in the breast tissue?
A. Tamoxifen
B. Anstrozole
C. Exemestane
D. Leuprolide
E. Flutamide
Answer: A. Tamoxifen
19. Which of the following drugs inhibits estrogen induced growth of breast cancer by competing with estrogen receptors?
A. Tamoxifen
B. Anstrozole
C. Exemestane
D. Leuprolide
E. Flutamide
Answer: A. Tamoxifen
20. Which of the following drugs causes vaginal bleeding and discharge due to estrogenic activity of drug?
A. Tamoxifen
B. Anstrozole
C. Exemestane
D. Leuprolide
E. Flutamide
Answer: A. Tamoxifen
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