MEDICOLOGY: Anticancer Drugs MCQS. 69

Tuesday, April 5, 2022

Anticancer Drugs MCQS. 69

01. Tumor markers are biochemical indicators of the presence of neoplastic proliferation detected in serum, plasma or other body fluids. Alpha-Fetoprotein is used for?
A. Colorectal cancer 
B. Hepatoblastoma
C. Hepatocellular carcinoma 
D. Prostate cancer 
E. A & B
F. B & C 

Answer: F. B & C

02. Which one of the following drugs is potent myelosuppressant microtubule inhibitor drug?
A. Vincristine 
B. Vinblastine
C. Vinorelbine
D. Paclitaxel
E. Docetaxel

Answer: B. Vinblastine
A, B, C drugs are derived from periwinkle plant, Vinca rosea so called vinca alkaloids. D & E are semisynthetic drugs.

03. Which one of the following drugs is less neurotoxic naturally synthesised microtubule inhibitor drug?
A. Vincristine 
B. Vinblastine
C. Vinorelbine
D. Paclitaxel
E. Docetaxel

Answer: C. Vinorelbine
A, B, C drugs are derived from periwinkle plant, Vinca rosea so called vinca alkaloids. D & E are semisynthetic drugs.

04. Which of the following drugs can cause hyperuricemia due to oxidation of purines that are from fragmenting DNA molecules?
A. Vincristine 
B. Vinblastine
C. Vinorelbine
D. A & B
E. All of the above 

Answer: E. All of the above 
A, B, C drugs are derived from periwinkle plant, Vinca rosea so called vinca alkaloids.

05. A drug that promotes polymerisation and stabilisation of the polymer rather than disassembly?
A. Vincristine 
B. Vinblastine
C. Vinorelbine
D. Paclitaxel 
E. All of the above 

Answer: D. Paclitaxel
Docetaxel and Paclitaxel promote stabilisation. While vinca alkaloids block the ability of tubulin to form microtubules. 

06. The phase in which the cell devides into two daughter cells?
A. M Phase 
B. G1 Phase
C. S Phase 
D. G2 Phase 
E. G0 Phase 

Answer: A. M phase 

07. The phase in RNA and enzymes topoisomeease I and Topoisomerase II are produced?
A. M Phase 
B. G1 Phase
C. S Phase 
D. G2 Phase 
E. G0 Phase 

Answer: D. G2 Phase 

08. The phase in which the cell is not committed to division?
A. M Phase 
B. G1 Phase
C. S Phase 
D. G2 Phase 
E. G0 Phase 

Answer: E. G0 Phase 

09. The phase in which DNA synthesis and replication occurs?
A. M Phase 
B. G1 Phase
C. S Phase 
D. G2 Phase 
E. G0 Phase 

Answer: C. S Phase 

 
10. The phase in which the RNA and the protein required for the specialized function of the cell are synthesised in preparation for DNA synthesis?
A. M Phase 
B. G1 Phase
C. S Phase 
D. G2 Phase 
E. G0 Phase 

Answer: B. G1 Phase 

11. Adverse effects of methotrexate can be reversed by administering following drug?
A. Allopurinol 
B. Leucovorin
C. Cytarabine
D. 6-mercaptopurine
E. Gemcitabine

Answer: B. Leucovorin
Leucovorin reversed the inhibition of dihydrofolate reductase (DHFR).

12. Which of the following anti tumour antibiotics drugs is cell cycle specific?
A. Doxorubicin 
B. Daunorubicin
C. Idarubicin
D. Mitoxantrone
E. Bleomycin

Answer: E. Bleomycin

13. Which of the following anti tumour drugs are anthracyclines antibiotics except?
A. Doxorubicin 
B. Daunorubicin
C. Idarubicin
D. Mitoxantrone
E. Bleomycin

Answer: E. Bleomycin
All others are anthracyclines antibiotics, these drugs can induce membrane lipid peroxidation, DNA strand scission, and direct oxidation of purines and pyrimidines bases, thiols and amines.

14. Which of the following anti tumour antibiotics drugs don't cause red coloration of urine?
A. Doxorubicin 
B. Daunorubicin
C. Idarubicin
D. Epirubicin
E. Bleomycin

Answer: E. Bleomycin
All others cause red coloration of urine due to dark red color of the anthracyclines drugs.

15. Which of the following anti tumour antibiotics drugs are inactivated in the GI tract?
A. Doxorubicin 
B. Daunorubicin
C. Idarubicin
D. A & B
E. All of these 

Answer: E. All of these 
Along with other anthracyclines drugs.

16. Which of the following drugs anti tumor antibiotics drugs is less cardio toxic than others?
A. Doxorubicin 
B. Daunorubicin
C. Liposomal Doxorubicin 
D. Idararubicin
E. Epirubicin

Answer: C. Liposomal Doxorubicin 
 
17. Which of the following drugs is selective estrogen modulator (SERM)?
A. Tamoxifen 
B. Anstrozole
C. Exemestane
D. Leuprolide
E. Flutamide

Answer: A. Tamoxifen 
Tamoxifen is an antagonist in breast tissue and an agonist in other tissues like bone and the endometrium.

18. Which of the following drugs competes with estrogen for binding to estrogen receptors in the breast tissue?
A. Tamoxifen 
B. Anstrozole
C. Exemestane
D. Leuprolide
E. Flutamide

Answer: A. Tamoxifen 

19.  Which of the following drugs inhibits estrogen induced growth of breast cancer by competing with estrogen receptors?
A. Tamoxifen 
B. Anstrozole
C. Exemestane
D. Leuprolide
E. Flutamide

Answer: A. Tamoxifen 

20. Which of the following drugs causes vaginal bleeding and discharge due to estrogenic activity of drug?
A. Tamoxifen 
B. Anstrozole
C. Exemestane
D. Leuprolide
E. Flutamide

Answer: A. Tamoxifen 



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